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. 2013 Sep 25;3:247. doi: 10.3389/fonc.2013.00247

Table 1.

Chelator families and their representative for metal complexation.

Natural chelator Desferrioxamine
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Acyclic polyaminocarboxylate ligands EDTA, Ethylenediaminetetraacetic acid
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DTPA, Diethylenetriaminepentaacetic acid
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Cyclic polyamines Cyclam, 1,4,8,11-tetraazacyclotetradecane
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Cyclen, 1,4,7,10-tetraazacyclododecane
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Cyclic polyaminocarboxylates and their derivatives DOTA, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
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TETA, 1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetraacetic acid
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NOTA, 1,4,7-triazacyclononane-1,4,7-triacetic acid
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Amines with rigid backbones Tachpyr, cis,cis-1,3,5-triaminocyclohexane
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Cross-bridged cyclic polyaminocarboxylates CB-TE2A, 1,4,8,11-tetraazabicyclo[6.6.2]hexadecane
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Bicyclic hexaamine Sar, sarcophagine
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Cyclic polyamines are also named polyaza macrocycles; note that the sarcophagine (bicyclic hexamines) belongs to this family. Adapted from Wadas et al. (60) and Brechbiel et al. (62).