Table 3.
Deregulated miRNA in desmoplastic medulloblastoma compared to normal cerebellum.
| Our miRNA profile (84) | Chromosomal localization | Fold change | Reference |
|---|---|---|---|
| DOWNREGULATED | |||
| hsa-miR-206 | 6p12.2 | −7.53 | (29) |
| hsa-miR-219-2-3p | 9q33.3 | −6.64 | (52) |
| hsa-miR-383 | 8p22 | −6.56 | (12, 55, 56) |
| hsa-miR-138 | 16q13.3/3p21.32 | −5.16 | (12, 14) |
| hsa-miR-323-3p | 14q32.2 | −4.96 | (12, 52) |
| hsa-miR-122 | 18q21.31 | −4.82 | |
| hsa-miR-105 | Xq28 | −4.66 | |
| hsa-miR-129-5p | 11p11.2/7q32.1 | −4.56 | (23) |
| hsa-miR-935 | 19q13.43 | −4.53 | (52) |
| hsa-miR-329 | 14q32.2 | −4.48 | |
| hsa-miR-129-3p | 11p11.2/7q32.1 | −4.43 | |
| hsa-miR-650 | 22q11.21 | −4.19 | |
| hsa-miR-184 | 15q24.3 | −4.14 | |
| hsa-miR-370 | 14q32.2 | −3.99 | (12) |
| hsa-miR-433 | 14q32.2 | −3.96 | (29) |
| hsa-miR-138-2* | 16q13.3/3p21.32 | −3.91 | |
| hsa-miR-487b | 14q32.2 | −3.82 | (29) |
| hsa-miR-487a | 14q32.2 | −3.78 | |
| hsa-miR-758 | 14q32.2 | −3.65 | |
| hsa-miR-485-5p | 14q32.2 | −3.60 | |
| hsa-miR-138-1* | 16q13.3/3p21.32 | −3.55 | |
| hsa-miR-382 | 14q32.2 | −3.53 | (12, 29) |
| hsa-miR-504 | Xq26.3 | −3.45 | (52) |
| hsa-miR-128 | 2q21.3/3p22.3 | −3.43 | (12, 14, 51, 59) |
| hsa-miR-490-5p | 7q33 | −3.42 | |
| hsa-miR-770-5p | 14q32.2 | −3.35 | |
| hsa-miR-410 | 14q32.2 | −3.30 | (29) |
| hsa-miR-432 | 14q32.2 | −3.29 | |
| hsa-miR-485-3p | 14q32.2 | −3.02 | |
| hsa-miR-490-3p | 7q33 | −2.88 | |
| hsa-miR-381 | 14q32.2 | −2.73 | (12) |
| hsa-miR-377* | 14q32.2 | −2.72 | |
| hsa-miR-7 | 15q25.3/19p13.3/9q21.32 | −2.72 | (12, 14) |
| hsa-miR-124 | 20p23.1/8q12.3/8p23.1 | −2.71 | (12, 14, 29, 48, 49) |
| hsa-miR-323-5p | 14q32.31 | −2.69 | (12) |
| hsa-miR-873 | 9p21.1 | −2.65 | |
| hsa-miR-129* | 11p11.2/7q32.1 | −2.63 | |
| hsa-miR-338-5p | 17q25.3 | −2.61 | (14) |
| hsa-miR-409-5p | 14q32.2 | −2.61 | |
| hsa-miR-874 | 5q31.2 | −2.46 | |
| hsa-miR-495 | 14q32.2 | −2.46 | (52) |
| hsa-miR-885-5p | 3p25.3 | −2.45 | |
| hsa-miR-376c | 14q32.2 | −2.43 | (52) |
| hsa-miR-299-5p | 14q32.2 | −2.41 | |
| hsa-miR-539 | 14q32.2 | −2.40 | (52) |
| hsa-miR-127-5p | 14q32.2 | −2.35 | (12, 29) |
| hsa-miR-127-3p | 14q32.2 | −2.35 | (52, 59) |
| hsa-miR-411* | 14q32.2 | −2.30 | |
| hsa-miR-125b-1* | 11q24.1/21q21.1 | −2.27 | |
| hsa-miR-411 | 14q32.2 | −2.23 | (29) |
| hsa-miR-379 | 14q32.2 | −2.22 | (29, 52) |
| hsa-miR-431* | 14q32.2 | −2.22 | |
| hsa-miR-767-5p | Xq28 | −2.20 | |
| hsa-miR-139-3p | 11q13.4 | −2.17 | |
| hsa-miR-154 | 14q32.2 | −2.16 | (12) |
| hsa-miR-1224-5p | 3q27.2 | −2.15 | |
| hsa-miR-187 | 18q12.1 | −2.14 | (12) |
| hsa-miR-95 | 4p16.1 | −2.10 | (14) |
| hsa-miR-369-5p | 14q32.2 | −2.05 | |
| hsa-miR-665 | 14q32.2 | −2.05 | |
| hsa-miR-494 | 14q32.2 | −2.03 | (52) |
| hsa-miR-134 | 14q32.2 | −2.03 | (12, 29) |
| hsa-miR-346 | 10q23.2 | −2.01 | (12, 13) |
| hsa-miR-324-5p | 17p13.1 | −2.00 | (12, 50) |
| UPREGULATED | |||
| hsa-miR-199b-3p | 9q33.3 | 4.56 | (12) |
| hsa-miR-199a-3p | 19p13.2/1q24.1 | 4.49 | |
| hsa-miR-199a-5p | 19p13.2/1q24.1 | 4.14 | (28) |
| hsa-miR-21 | 17q22 | 3.70 | (12–14, 29, 31) |
| hsa-miR-214 | 1q24.2 | 3.59 | |
| hsa-miR-19a | 13q31.3 | 3.11 | (12–14) |
| hsa-miR-92a-1* | 13q31.3/Xq26.2 | 3.06 | |
| hsa-miR-214* | 1q24.2 | 2.93 | |
| hsa-miR-34a | 1p36.23 | 2.78 | (13, 30, 53) |
| hsa-miR-18b | Xq26.2 | 2.74 | |
| hsa-miR-422a | 15q22.2 | 2.72 | (14) |
| hsa-miR-34a* | 1p36.23 | 2.58 | (14) |
| hsa-miR-574-3p | 4p14 | 2.49 | (14) |
| hsa-miR-378 | 5q32 | 2.39 | (14) |
| hsa-miR-1244 | 12p13.2/12p13.31/2q37.1/5q23.1 | 2.39 | |
| hsa-miR-18a | 13q31.3 | 2.39 | (12–14) |
| hsa-miR-93* | 7q22.1 | 2.26 | |
| hsa-miR-497 | 17p13.1 | 2.17 | (13) |
| hsa-miR-195* | 17p13.1 | 2.14 | |
| hsa-miR-216a | 2p16.1 | 2.07 | (14) |