Table 4.

miRNAs validated by functional assay in human and mouse medulloblastoma.

miRNA	Deregulation	Cells	Functional assaya	Target genes	Reference
124	Down	Primary human MB, cell lines	↑Cell cycle progression at G1	CDK6	(48, 49)
			↓Cell proliferation	SLC16A1
324-5p	Down	Primary human and mouse MB, cell lines	↓Cell proliferation	SMO	(50)
326				GLI1
125p
9	Down	Primary human MB, cell lines	↑Apoptosis	Trkc	(12)
125a			↓Cell proliferation
199b-5p	Up	Primary human and mouse MB, cell lines	↑Cell cycle progression at G1	HES1	(28)
			↓Cell proliferation
128	Down	Primary human and mouse MB	↓Cell proliferation	BMI-1	(51)
			↑Cell senescence
21	Up	Primary human MB, cell lines	↓Cell migration	PDCD4	(31)
935	Down	Primary human MB, cell lines	–	KIAA0232	(52 )
				SLC5A3
				TBC1D9
				ZFAND6
34a	Down	MB cell lines	↑Apoptosis	MAGE-A	(30, 53)
			↑Cell cycle progression at S/phase and G2/M	Dll1
			↓Cell proliferation	Notch1
			↑Cell senescence	Notch2
512-5p	Down	Primary human MB, cell lines	–	MYCC	(54 )
383	Down	Primary human MB, cell lines	↑Apoptosis	PRDX3	(55, 56)
			↑Cell cycle progression at G1
			↓Cell proliferation
183 ∼96 ∼	Down	MB cell lines	↑Cell cycle progression at	AKT	(57)
182			G0/G1 and G2
			↓Cell migration
			↓Cell proliferation
218	Down	MB cell lines	↓Cell migration	CDK6	(58)
			↓Cell proliferation	REST

Underlined miRNAs are miRNAs also found deregulated in the present study;

^aresults of ectopic expression or knockdown assays; MB = medulloblastoma.