Table 2.
ROI | fMRI and CREB1
|
fMRI and RP
|
||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Condition | x a | y a | z a | z Scoreb | P Value | Valence of Subtraction | APc vs PHd | Condition | x a | y a | z a | z Scoreb | P Value | Valence of Regression | APc vs PHd | |
Left amygdala | Happy | −22 | −6 | −20 | 4.41 | 1 × 10−5 | − | AP | … | |||||||
Left FOC | … | Fearful | −32 | 18 | −16 | 4.55 | 5 × 10−6 | + | AP | |||||||
Left INS | Angry | −38 | −4 | 0 | 3.97 | 7.1 × 10−5, e | − | PH | Angry | −40 | −6 | −2 | 3.86 | 1.13 × 10−4, e | + | AP |
Fearful | −36 | −10 | 16 | 3.84 | 1.22 × 10−4 | − | PH | Fearful | −28 | 12 | −14 | 4.00 | 6.2 × 10−5 | + | AP | |
Sad | −34 | −10 | 16 | 4.40 | 1.0 × 10−5 | − | AP | … | ||||||||
Left anterior cingulate | … | Happy | −8 | 12 | 34 | 3.91 | 1.0 × 10−4 | + | AP | |||||||
Right amygdala | … | … | ||||||||||||||
Right FOC | … | Fearful | 26 | 16 | −16 | 4.29 | 1.8 × 10−5 | + | AP | |||||||
Sad | 26 | 16 | −16 | 3.56 | 3.7 × 10−4 | + | AP | |||||||||
Neutral | 48 | 32 | −16 | 3.55 | 3.9 × 10−4 | + | AP | |||||||||
Right INS | Angry | 38 | 0 | 2 | 3.39 | 7.02 × 10−4 | − | AP | … | |||||||
Fearful | 38 | 2 | 2 | 3.79 | 1.5 × 10−4, e | − | PH | Fearful | 30 | 24 | −2 | 3.59 | 3.32 × 10−4, e | − | AP | |
Neutral | 38 | 0 | 2 | 3.65 | 2.65 × 10−4 | − | AP | … | ||||||||
Right anterior cingulate | … | Sad | 8 | 38 | 20 | 3.96 | 1.0 × 10−4 | + | AP |
Abbreviations: AP, a priori; CREB1, cyclic adenosine monophosphate response element binding protein gene; ellipses, no data; fMRI, functional magnetic resonance imaging; FOC, orbitofrontal cortex; ICBM, International Consortium for Brain Mapping; INS, insula; PH, post hoc; ROI, region of interest; RP, relative preference; −, negative valence to the genotype-based subtraction or key press–based regression; +, positive valence to the genotype-based subtraction or key press–based regression.
Variables x, y, and z refer to coordinates of peak differential activation in ICBM152 space.
Absolute z score.
Activation survives clusterwise AP correction, P <.05.
Activation survives clusterwise PH correction, P <.05/4.
These indicate colocalizing activations beyond 5 voxels.