Table 2.

Peak Differential Activation to Emotional Faces in Regions of Interest

ROI	fMRI and CREB1								fMRI and RP
	Condition	x a	y a	z a	z Scoreb	P Value	Valence of Subtraction	APc vs PHd	Condition	x a	y a	z a	z Scoreb	P Value	Valence of Regression	APc vs PHd
Left amygdala	Happy	−22	−6	−20	4.41	1 × 10−5	−	AP					…
Left FOC					…				Fearful	−32	18	−16	4.55	5 × 10−6	+	AP
Left INS	Angry	−38	−4	0	3.97	7.1 × 10−5, e	−	PH	Angry	−40	−6	−2	3.86	1.13 × 10−4, e	+	AP
	Fearful	−36	−10	16	3.84	1.22 × 10−4	−	PH	Fearful	−28	12	−14	4.00	6.2 × 10−5	+	AP
	Sad	−34	−10	16	4.40	1.0 × 10−5	−	AP					…
Left anterior cingulate					…				Happy	−8	12	34	3.91	1.0 × 10−4	+	AP
Right amygdala					…								…
Right FOC					…				Fearful	26	16	−16	4.29	1.8 × 10−5	+	AP
									Sad	26	16	−16	3.56	3.7 × 10−4	+	AP
									Neutral	48	32	−16	3.55	3.9 × 10−4	+	AP
Right INS	Angry	38	0	2	3.39	7.02 × 10−4	−	AP					…
	Fearful	38	2	2	3.79	1.5 × 10−4, e	−	PH	Fearful	30	24	−2	3.59	3.32 × 10−4, e	−	AP
	Neutral	38	0	2	3.65	2.65 × 10−4	−	AP					…
Right anterior cingulate					…				Sad	8	38	20	3.96	1.0 × 10−4	+	AP

Abbreviations: AP, a priori; CREB1, cyclic adenosine monophosphate response element binding protein gene; ellipses, no data; fMRI, functional magnetic resonance imaging; FOC, orbitofrontal cortex; ICBM, International Consortium for Brain Mapping; INS, insula; PH, post hoc; ROI, region of interest; RP, relative preference; −, negative valence to the genotype-based subtraction or key press–based regression; +, positive valence to the genotype-based subtraction or key press–based regression.

^aVariables x, y, and z refer to coordinates of peak differential activation in ICBM152 space.

^bAbsolute z score.

^cActivation survives clusterwise AP correction, P <.05.

^dActivation survives clusterwise PH correction, P <.05/4.

^eThese indicate colocalizing activations beyond 5 voxels.