Table 2.

Mean change in the domain scores of the SCNS-P&C, HADS and SF12 compared to baseline within each treatment group and differences between groups

Characteristic	Follow-up, months	Treatment group Mean change (SD)		Absolute difference between groups LSMa (95%CI)
		Control	Intervention	Difference between groups	P-value
SCNS-P&Cb	1	−0.6 (6.5)	−1.2 (6.2)	0.19 (−1.19 to 1.56)	0.791
Health care service needs	3	−0.8 (8.2)	−2.4 (6.5)	0.45 (−1.13 to 2.04)	0.575
	6	−1.5 (8.4)	−2.5 (8.1)	0.23 (−1.65 to 2.10)	0.811
SCNS-P&C	1	−0.6 (7.1)	−0.8 (7.0)	0.65 (−0.98 to 2.28)	0.434
Psychology and emotional needs	3	−1.4 (7.6)	−2.0 (7.2)	0.33 (−1.39 to 2.05)	0.709
	6	−2.5 (9.7)	−2.0 (8.3)	1.45 (−0.80 to 3.69)	0.205
SCNS-P&C	1	0.1 (3.9)	−0.6 (3.9)	0.06 (−0.80 to 0.92)	0.892
Work and social needs	3	−0.0 (4.3)	−1.0 (3.9)	0.32 (−0.60 to 1.24)	0.497
	6	−1.2 (4.8)	−1.5 (4.4)	0.36 (−0.72 to 1.44)	0.516
SCNS-P&C	1	−0.4 (4.7)	−0.9 (4.2)	0.12 (−0.86 to 1.11)	0.804
Information needs	3	−0.5 (5.2)	−1.7 (4.5)	0.51 (−0.62 to 1.64)	0.373
	6	−1.3 (5.6)	−2.2 (5.7)	0.01 (−1.24 to 1.27)	0.981
SCNS-P&C	1	−0.3 (5.0)	−1.1 (6.0)	0.18 (−1.06 to 1.42)	0.772
Total number of unmet needs	3	−0.8 (6.0)	−2.3 (4.9)	0.49 (−0.76 to 1.73)	0.441
	6	−1.6 (6.8)	−2.6 (6.4)	0.16 (−1.40 to 1.72)	0.841
HADSc anxiety score	1	−0.5 (2.8)	−0.8 (3.0)	0.05 (−0.63 to 0.73)	0.886
	3	−0.4 (3.2)	−1.0 (3.8)	0.33 (−0.51 to 1.18)	0.437
	6	−1.1 (4.0)	−0.7 (3.8)	0.82 (−0.18 to 1.82)	0.109
HADS depression score	1	0.3 (2.7)	−0.1 (2.5)	0.22 (−0.39 to 0.83)	0.473
	3	0.4 (3.5)	−0.0 (3.2)	0.21 (−0.62 to 1.03)	0.624
	6	−0.1 (3.9)	0.3 (3.9)	0.73 (−0.28 to 1.74)	0.154
SF-12d Physical component score	1	0.0 (6.6)	−0.7 (8.2)	0.61 (−1.09 to 2.31)	0.482
	3	−0.0 (7.3)	−1.0 (8.0)	0.85 (−0.99 to 2.70)	0.362
	6	0.1 (7.6)	−0.0 (9.4)	0.14 (−2.03 to 2.30)	0.902
SF-12 Mental component score	1	−0.4 (9.1)	1.2 (8.4)	0.45 (−1.56 to 2.46)	0.662
	3	−0.4 (9.0)	2.4 (9.3)	1.49 (−0.68 to 3.66)	0.178
	6	0.6 (10.9)	2.1 (9.8)	0.13 (−2.50 to 2.76)	0.924

^aLSM = Least Squares Mean.

^bSCNS-P&C domain scores normalised to range of 0–100 .

^cHADS Anxiety and Depression scores range 0–21. Scores ≥8 indicate clinical anxiety or depression.

^dSF-12 score range from 0–100. Higher score indicates better health related quality of life.