Table 3.

Mean changes from baseline to follow-up time points in selected domains of the SCNS-P&C, HADS and SF-12, adjusted forbaseline anxiety (HADS Anxiety scale >8 and ≥8) and Depression (HADS Depression scale >8 and ≥8)

Characteristic	Follow-up, months	Treatment group mean change (SD) from baseline		Absolute difference between groups LSM (95% CI)	P-value
		Control	Intervention
Mental and Social Health	HADS Anxiety ≥8
SCNS-P&Ca Psychology and emotional needs	1	−0.1 (0.5)	−0.1 (0.5)	0.06 (−0.10 to 0.23)	0.443
	3	−0.1 (0.6)	−0.1 (0.6)	0.05 (−0.13 to 0.23)	0.597
	6	−0.4 (0.7)	−0.2 (0.6)	0.20 (−0.01 to 0.42)	0.063b
SCNS-P&C Work and social needs	1	0.0 (0.6)	−0.1 (0.6)	0.00 (−0.18 to 0.18)	0.984
	3	0.0 (0.6)	−0.2 (0.6)	0.16 (−0.02 to 0.35)	0.087d
	6	−0.3 (0.7)	−0.3 (0.7)	0.05 (−0.17 to 0.28)	0.631
SF-12c Mental component score	1	−0.8(10.6)	2.1 (9.8)	1.79 (−1.23 to 4.80)	0.244
	3	−1.4 (10.0)	3.6 (10.4)	3.59 (0.41 to 6.77)	0.027d
	6	1.9 (11.5)	3.4 (11.1)	0.39 (−3.33 to 4.11)	0.835
	HADS Depression≥8
HADSe anxiety score	1	−1.5 (3.2)	−1.2 (3.7)	0.30 (−1.30 to 1.91)	0.708
	3	−1.6 (3.7)	−1.9 (4.1)	0.24 (−1.69 to 2.18)	0.801
	6	−3.9 (5.2)	−1.2 (4.8)	2.67 (0.07 to 5.26)	0.044d
SF-12 Mental component scorea	1	−0.8 (6.9)	−1.3 (7.5)	0.15 (−3.11 to 3.41)	0.927
	3	−3.4 (7.0)	−1.8 (7.2)	1.95 (−1.45 to 5.35)	0.255
	6	−7.5 (9.1)	−3.0 (8.2)	4.15 (−0.63 to 8.93)	0.087d
Physical characteristics	HADS Anxiety <8
SF-12 Physical component score	1	−0.6 (6.1)	1.7 (4.5)	2.15 (0.10 to 4.20)	0.040d
	3	−0.4 (5.9)	1.7 (6.7)	1.98 (−0.35 to 4.31)	0.094d
	6	−0.2 (6.5)	2.3 (5.9)	2.38 (−0.12 to 4.88)	0.062d
	HADS Anxiety≥8
SF-12 Physical component scorec	1	0.6 (7.0)	−2.0 (9.4)	2.07 (−0.47 to 4.61)	0.110
	3	0.4 (8.5)	−2.8 (8.4)	2.70 (−0.03 to 5.44)	0.053b
	6	0.4 (8.5)	−1.4 (10.8)	1.15 (−2.19 to 4.50)	0.495

^aSCNS — P&C = Supportive Care Needs Survey — Partners and Carers. Scores normalised to 0–100.

^bFavours control.

^cSF-12 = Short form 12.

^dFavours intervention.

HADS = Hospital Anxiety and Depression Score.