Table 2.
κ Statistics for agreement of ER and PR status from different data sources by study site, tumor characteristics, and cases' demographic characteristics
| ER |
PR |
Overall ER/PR |
||||
|---|---|---|---|---|---|---|
| No. of cases | κ (95% CI) | No. of cases | κ (95% CI) | No. of cases | κ (95% CI) | |
| Study site | ||||||
| Detroit | 286 | 0.68 (0.59–0.76) | 261 | 0.64 (0.55–0.73) | 257 | 0.56 (0.48–0.64) |
| Los Angeles | 762 | 0.70 (0.65–0.76) | 665 | 0.58 (0.52–0.65) | 662 | 0.55 (0.49–0.60) |
| P * | 0.62 | 0.32 | 0.71 | |||
| Calendar year of diagnosis | ||||||
| 1994 | 143 | 0.54 (0.41–0.67) | 137 | 0.39 (0.24–0.54) | 136 | 0.35 (0.24–0.46) |
| 1995 | 179 | 0.66 (0.55–0.77) | 166 | 0.59 (0.47–0.71) | 166 | 0.52 (0.42–0.62) |
| 1996 | 325 | 0.78 (0.71–0.85) | 268 | 0.65 (0.56–0.74) | 265 | 0.62 (0.55–0.70) |
| 1997 | 302 | 0.72 (0.64–0.80) | 268 | 0.65 (0.56–0.74) | 266 | 0.60 (0.53–0.68) |
| 1998 | 99 | 0.66 (0.51–0.82) | 87 | 0.67 (0.51–0.83) | 86 | 0.56 (0.42–0.69) |
| P * | 0.02 | 0.04 | 0.001 | |||
| Tumor size (source, SEER), cm | ||||||
| <2 | 472 | 0.64 (0.57–0.72) | 408 | 0.57 (0.49–0.66) | 404 | 0.53 (0.46–0.60) |
| 2–4.9 | 445 | 0.75 (0.69–0.81) | 396 | 0.61 (0.54–0.69) | 394 | 0.57 (0.51–0.63) |
| ≥5 | 88 | 0.57 (0.41–0.74) | 84 | 0.53 (0.36–0.70) | 83 | 0.45 (0.31–0.59) |
| Diffuse | 14 | 13 | 13 | |||
| Unknown | 29 | 25 | 25 | |||
| P * | 0.03 | 0.62 | 0.26 | |||
| Tumor stage (source, SEER) | ||||||
| Localized disease | 615 | 0.70 (0.65–0.76) | 535 | 0.59 (0.52–0.66) | 531 | 0.56 (0.50–0.61) |
| Regional disease (extension to lymph nodes) | 409 | 0.68 (0.60–0.75) | 370 | 0.63 (0.55–0.71) | 367 | 0.54 (0.48–0.61) |
| Distant metastases | 23 | 0.82 (0.60–1.00) | 20 | 0.38 (−0.02 to 0.78) | 20 | 0.51 (0.25–0.76) |
| Unknown | 1 | 1 | 1 | |||
| P * | 0.45 | 0.42 | 0.91 | |||
| Age at diagnosis | ||||||
| <40 | 200 | 0.74 (0.65–0.83) | 188 | 0.62 (0.51–0.73) | 186 | 0.59 (0.50–0.68) |
| 40–44 | 182 | 0.63 (0.53–0.74) | 168 | 0.62 (0.50–0.74) | 167 | 0.51 (0.42–0.61) |
| 45–49 | 164 | 0.70 (0.59–0.81) | 142 | 0.66 (0.54–0.79) | 141 | 0.58 (0.48–0.69) |
| 50–54 | 187 | 0.72 (0.61–0.83) | 163 | 0.71 (0.60–0.82) | 161 | 0.62 (0.52–0.72) |
| 55–59 | 153 | 0.70 (0.58–0.82) | 129 | 0.54 (0.40–0.69) | 128 | 0.51 (0.39–0.63) |
| 60–64 | 162 | 0.62 (0.48–0.76) | 136 | 0.36 (0.20–0.53) | 136 | 0.41 (0.29–0.53) |
| P * | 0.60 | 0.02 | 0.10 | |||
| Race | ||||||
| White | 614 | 0.66 (0.60–0.72) | 544 | 0.60 (0.53–0.67) | 542 | 0.53 (0.48–0.59) |
| African American | 434 | 0.73 (0.67–0.79) | 382 | 0.59 (0.52–0.67) | 377 | 0.56 (0.50–0.63) |
| P * | 0.11 | 0.98 | 0.51 | |||
*
P value from the κ homogeneity χ2 test of Fleiss.