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. 2013 Jul-Aug;6(4):107–114.

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© 2013 by International Society of Gastrointestinal Oncology

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Figure 4. — ISH staining for VEGF mRNA. (A) Normal hepatocyte (arrow) from a control case, showing faint expression of VEGF mRNA. (B) A case of CHC without cirrhosis (A1F1), showing mild (+) green signal for VEGF mRNA in a hepatocyte (arrow). (C) A case of CHC with cirrhosis (A2F3) with a cirrhotic nodule showing moderate (++) green signal for VEGF mRNA in a hepatocyte (arrow). (D) A case of moderately differentiated HCC, showing intense (+++) green signal for VEGF mRNA in a hepatocyte (arrow). (A–D) ISH; ×625.