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. 2013 Jul 8;30(3):1059–1066. doi: 10.3892/or.2013.2601

Figure 1.

Figure 1

Inhibitory effect of cantharidin (CAN) and norcantharidin (NCTD) on the biological behavior of MCF-7 cells. (A) Exposure to various concentrations of CAN and NCTD resulted in dose- and time-dependent growth inhibition. (B) CAN and NCTD treatment inhibited the clone formation ability of MCF-7 cells in a dose-dependent manner. (C) Following CAN and NCTD treatment, the early apoptotic (Annexin V+/PI−) cell populations increased significantly in a dose-dependent manner. (D) CAN and NCTD treatment inhibited MCF-7 cell adhesion in a dose-dependent manner. (E) CAN and NCTD treatment inhibited MCF-7 cell migration in a time-dependent manner. *P<0.05; **P<0.01 indicate significant differences from the respective control groups.