Figure 3.

Cantharidin (CAN) and norcantharidin (NCTD) inhibit the ability of MCF-7 cells to adhere to platelets through the downregulation of α2 integrin. (A) CAN and NCTD downregulated the mRNA expression of α2 integrin, but had no effect on β1 integrin. (B) CAN and NCTD downregulated the abundance of α2 integrin on the surface of MCF-7 cells. (C) P1E6 repressed the adhesion between MCF-7 cells and platelets, and attenuated the repressed adhesion induced by CAN and NCTD. ^*P<0.05; ^**P<0.01 indicate significant differences from the respective control groups. ^&P<0.01 indicates significant differences between fold inductions.