. 2013 Sep 10;178(7):1076–1084. doi: 10.1093/aje/kwt086

Table 3.

Risk of Coronary Heart Disease per 1.03-mmol/L Increase in Total Cholesterol and LDL Cholesterol Levels, According to hs-CRP Category at Visit 4 (1996–1997), Atherosclerosis Risk in Communities Study, United States, 1987–2008

	hs-CRP Level
	Age <65 Years						Age ≥65 Years
	<2 mg/L (n = 2,483)		≥2 mg/L (n = 3,146)		Overall (n = 5,629)		<2 mg/L (n = 1,446)		≥2 mg/L (n = 1,872)		Overall (n = 3,318)
	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI
Total cholesterol
Model 1^a	1.33	1.15, 1.55	1.31	1.17, 1.46	1.32	1.20, 1.44	1.43	1.22, 1.68	1.11*	0.98, 1.26	1.23	1.11, 1.35
Model 2^b	1.35	1.16, 1.57	1.35	1.20, 1.51	1.35	1.24, 1.48	1.45	1.23, 1.70	1.11,*	0.98, 1.26	1.23	1.11, 1.36
Model 3^c	1.39	1.20, 1.61	1.37	1.22, 1.53	1.38	1.26, 1.52	1.46	1.24, 1.71	1.14,*	1.00, 1.29	1.26	1.14, 1.39
LDL cholesterol
Model 1	1.42	1.21, 1.67	1.36	1.21, 1.53	1.39	1.26, 1.53	1.39	1.17, 1.64	1.17	1.02, 1.34	1.25	1.13, 1.39
Model 2	1.45	1.24, 1.70	1.41	1.25, 1.59	1.43	1.30, 1.57	1.42	1.20, 1.68	1.16**	1.02, 1.33	1.26	1.13, 1.40
Model 3	1.43	1.21, 1.67	1.40	1.24, 1.58	1.41	1.28, 1.55	1.42	1.18, 1.67	1.10**	0.96, 1.26	1.22	1.09, 1.36

Abbreviations: CI, confidence interval; HR, hazard ratio; hs-CRP, high-sensitivity C-reactive protein; LDL, low-density lipoprotein.

* P < 0.05 (compared with lower hs-CRP group); ** P < 0.05 (compared with lower age group).

^a Model 1 adjusted for age, sex, and race.

^b Model 2 adjusted for age, sex, race, current smoking, diabetes, hypertension, and body mass index.

^c Model 3 adjusted for age, sex, race, current smoking, diabetes, hypertension, body mass index, and high-density lipoprotein cholesterol.