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. 2013 Apr 10;7(3):209–214. doi: 10.4161/pri.24628

Table 1. Оccurrence of fragmentation-promoting amino acid residues in yeast PrDs.

Amino acid
Prionogenic protein15,27-31,
Average in
S. cerevisiae
  Sup35 Rnq1 Ure3 Cyc8 Sfp1 Swi1 Mot3
Tyr
16.1
5.9
0
0.6
1.3
1.72
5.7
3.4
Trp
0
0
0
0
0
0.19
0
1
Phe
3.2
3.6
2.4
0.6
0
4.4
2.0
4.5
Ala
4.8
5.1
1.2
20.5
8.9
6.1
8.8
5.6
His
0
1.6
1.2
2.3
7.6
0.8
7.5
2.1
Ser
3.2
15.4
11.8
2.8
13.9
10.7
10.2
8.9
Thr
0
0.8
5.9
1.7
8.9
7.6
5.0
5.9
Cys
0
0
0
0
0
0.2
0
1.3
Met 0.8 2.0 2.4 1.1 5.1 1.7 2.4 2.1

Numbers represent percentages of amino acid residues in PrDs of indicated proteins. The extents of PrDs were taken from Alberti et al.15 Amino acids are in order of decreasing stimulatory effect on fragmentation (top to bottom).26 Bold indicates the most abundant fragmentation-promoting residues.