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. 2013 Jul 1;41(17):8061–8071. doi: 10.1093/nar/gkt586

Figure 4.

Figure 4.

The position transition patterns of estrogen-responsive genes with respect to Pol II and ERα complexes and examples of positional transition of genes with respect to Pol II and ERα ChIA-PET complexes. (A) anchor-to-anchor, (B) anchor-to-loop, (C) anchor-to-stand-alone. A brown arrow represents a gene. The figure shows the positions and relationships of genes (RefSeq), Pol II complex anchor regions (Pol II Int), ERα complex anchor regions (ERα Int) and ERα ChIP-seq binding sites in the absence and presence of estrogen for three example genes: (A) anchor-to-anchor, gene: MYB; (B) anchor-to-loop, gene: CALM1; (C) anchor-to-stand-alone, gene: TLE1. The estrogen treatment conditions are color-coded with green (absence) and red (presence). The black arrows indicate one of Pol II anchor regions in the absence of ligand; a line in the chromatin interaction graph indicate the DNA region is involved in a chromatin complex.