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. 2013 Jul 1;41(17):8308–8318. doi: 10.1093/nar/gkt587

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Dyskerin KD drives VEGF mRNA translation in breast cancer cells. Total (left) and polysome-associated (right) VEGF mRNA levels assessed by real-time PCR after DKC1 KD in MCF7 (A) and MDA-MB231 cells (C). Representative polysomal profiles are shown. VEGF protein levels in supernatant and in whole cell extracts are also reported for MCF-7 (B) and MDA-MB231 cells (D). siRNA transfection was performed 96 h before cell harvesting. Histograms represent means and SDs from three independent experiments. P < 0.05 is considered significant.