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Proposed model for CYP1A1 gene regulation by AhR and ERα. (A) In the absence of estradiol, when TCDD is added in the media, AhR /Arnt binds the XRE’s located in the CYP1A1 promoter. At the same time, the histone variant H2A.Z is removed from the XRE’s. (B) In the presence of estradiol, ERα displaces AhR /Arnt by promoting DNA methylation on the XRE’s of the CYP1A1 promoter, thus resulting in less AhR activating surfaces available to stimulate CYP1A1 expression.
