Figure 6.

The regulation of acs expression. The expression of acs is regulated by genes involved in glucose repression (cyaA, crp, crr and ptsI). A modification of the glycolytic flux has indirect consequences on acs expression (ptsG, pgi, pfkA). Genes of the TCA cycle are needed for acetate utilization and mutants in these enzymes shut down acs transcription by a yet unknown mechanism. The red and green routes are schematic representations of the flux direction when cells grow on glucose and acetate, respectively.