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Pharmacodynamics in mice. (A) Single doses of bGCSF (10 µg/kg) and Ab-bGCSF L0 and Ab-bGCSF L1 (50 µg/kg) were administrated by subcutaneous (s.c.) injection into BALB/c mice (3 per group). Blood was collected and analyzed for neutrophils by FACS using fluorophore-labeled anti-CD45, anti-CD11b, and anti-Ly-6G antibodies. (B) Representative flow cytometric analyses of mouse neutrophil populations after treatments with bGCSF, Ab-bGCSF L0 and Ab-bGCSF L1.
