Table 1.
Trabecular and cortical microcomputed tomography (mCT) analyses of femora from 12-week-old wild-type (WT) and mitogen-activated protein kinase phosphatase 1 (Mkp1) knockout (KO) female mice. Data are presented as group mean±S.E.M.
| WT | KO | |
|---|---|---|
|
|
|
|
| Measurements | ||
| Trabecular BV/TV (%) | 0.366±0.017 | 0.217±0.011a |
| Trabecular BS/BV (mm/mm2) | 37.33±1.56 | 47.87±0.95a |
| Tb.Th (μm) | 0.054±0.002 | 0.042±0.001a |
| Tb.N (1/mm) | 6.78±0.06 | 5.174±0.19a |
| Tb.Sp (mm) | 0.093±0.03 | 0.1527±0.008a |
| Cortical mean thickness (mm) | 0.18±0.004 | 0.166±0.004c |
| Cortical Iyy (mm4) | 0.14±0.004 | 0.12±0.007c |
| Cortical inner perimeter (mm) | 3.88±0.03 | 3.74±0.05c |
| Cortical outer perimeter (mm) | 4.99±0.03 | 4.78±0.07c |
| Cortical area (mm2) | 0.75±0.015 | 0.68±0.02c |
| Trabecular BMC (mg) | 0.857±0.02 | 0.595±0.03a |
| Trabecular TMD (mg/cc) | 505.46±4.34 | 485.62±5.54c |
| Cortical BMC (mg) | 2.89±0.06 | 2.59±0.10c |
| Cortical TMD (mg/cc) | 1009.1±6.98 | 1011.3±6.72 |
|
|
||
BV, bone volume; BS, bone surface; TV, total volume; Tb.N, trabecular number; Tb.Th, trabecular thickness; Tb.Sp, trabecular spacing; Iyy, bending moment of inertia for the medial–lateral axis; BMC, bone mineral content; TMD, tissue mineral density.
a
P<0 001 and
c
P<0 05 versus WT(n=4–6).