Table 2.

Trabecular and cortical microcomputed tomography (mCT) analyses of tibiae from 12-week-old wild-type (WT) and mitogen-activated protein kinase phosphatase 1 (Mkp1) knockout (KO) female mice. Data are presented as group mean±S.E.M.

	WT	KO
Measurements
Trabecular BV/TV (%)	0.344±0.017	0.217±0.008a
Trabecular BS/BV (mm/mm2)	38.64±1.64	47.11±1.37b
Tb.Th (μm)	0.052±0.002	0.043±0.001b
Tb.N (1/mm)	6.59±0.07	5.1±0.17a
Tb.Sp (mm)	0.099±0.003	0.155±0.006a
Cortical mean thickness (mm)	0.231±0.003	0.22±0.003c
Cortical Iyy (mm4)	0.056±0.002	0.048±0.002b
Cortical inner perimeter (mm)	1.98±0.03	1.98±0.03
Cortical outer perimeter (mm)	3.42±0.024	3.35±0.03
Cortical area (mm2)	0.60±0.007	0.57±0.01b
Trabecular BMC (mg)	0.46±0.02	0.30±0.01a
Trabecular TMD (mg/cc)	540.35±7.52	514.23±10.91
Cortical BMC (mg)	1.3±0.02	1.18±0.03b
Cortical TMD (mg/cc)	1130.6±1.95	1097±10.05b
Cortical BVF	0.309±0.006	0.301±0.008

BV, bone volume; TV, total volume; BS, bone surface; Tb.N, trabecular number; Tb.Th, trabecular thickness; Tb.Sp, trabecular spacing; Iyy, bending moment of inertia for the medial–lateral axis; BMC, bone mineral content; TMD, tissue mineral density; BVF, bone volume fraction.

^aP<0 001,

^bP<0 01, and

^cP<0 05 versus WT (n=4–6).