Fig. 1.

Binding specificity of anti-capsular mAbs. Synthetic γd- and γlPGA 25mer were immobilized to separate sensor chips at 80 and 90 RU, respectively. mAb binding was analyzed in a two-fold dilution series at a mAb concentration of 5.5–333 nM to the γdPGA coated surface (left), and at a mAb concentration range of 26–833 nM to the γlPGA coated surface (right). The corresponding sensorgrams are given as a function of response generated over time for each mAb concentration. Note the substantial differences in the magnitude of response for binding of d versus L antigens.