Table 1.

Binding and immunochemical properties of anti-capsular mAbs

		γdPGA					γlPGA
mAb	Subclass	KDa	KDb	KIc	RUmax	mAb:Ag	KDd	KDb	KIc	RUmax	mAb:Ag
F24F2	IgG3	0.5	13	73	6800	1.8	nt	260	>500	1300	0.3
F24G7	IgG3	0.36	34	340	10000	2.7	nt	260	>500	4000	1.0
F26G3	IgG3	0.37	11	48	7300	2.0	nt	280	>500	300	0.07
F26G4	IgG3	0.51	20	98	7800	2.1	nt	160	>500	4500	1.1

^aIntrinsic affinity using fluorescence perturbation (µM), results adapted from Kozel et al., 2007

^bFunctional affinity using SPR (nM)

^cInhibition constant using fluid and solid phase antigen in SPR format (µM)

^dIntrinsic affinity using fluorescence perturbation (µM); nt, not tested