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. 2013 Sep 25;8(9):e75472. doi: 10.1371/journal.pone.0075472

Figure 2. Jak2 K915X/+ mice have elevated megakaryocytes and platelets.

Figure 2

(A) Bone marrow sections were prepared from 12 week Jak2 +/+ and Jak2 K915X/+ mice and stained with H and E. Representative sections are illustrated at 20x magnification. Megakaryocytes are indicated by an asterisk. (B) Platelets from male and female wild type, Jak2 +/- and Jak2 K915X mice at 8 wk of age were monitored. (C) Red blood cells were evaluated from male and female mice at 8 wk of age from WT, Jak2 +/- and Jak2 K915X/+ mice. Jak2 +/+ or JAK2 Control mice were littermate controls of Jak2 +/- or Jak2 K915X/+ breedings, respectively. Statistically significant differences between groups are denoted as *, p< 0.05 and **, p<0.0001. Each group has n=20-30.