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. 2013 Sep 25;8(9):e75253. doi: 10.1371/journal.pone.0075253

Figure 3. HH/GLI signaling regulates hTERT mRNA expression.

Figure 3

A: HT29 cells stably expressing empty vector (V), GLI1 (GLI1) or GLI2ΔN (GLI2ΔN) were analyzed for hTERT, GLI1 and GLI2 mRNA expression determined by Real-Time PCR. B: Exposure of HT29 cells to GANT61 (20 µM; 0–72 hr) reduced expression of hTERT mRNA, determined by Real-Time PCR. C: DU145, D: U87 cells were exposed to GANT61 (20 µM; 48 hr or 24 hr respectively) and GLI1, GLI2 and hTERT mRNA was measured by Real-time PCR. Data represent the mean ± SD of 3 determinations. *p<0.05.