Table 3. Estimated haplotype frequencies and ORs with 95% CI for overall IS, as compared to controls, in the discovery sample and the replication sample.

	Discovery sample, SAHLSIS			Replication sample, LSR, MDC ≤ 70 years			Replication sample, LSR, MDC
Haplotype	Estimated frequency (%)	OR (95% CI)‡	OR (95% CI)§	Estimated frequency (%)	OR (95% CI)‡	OR (95% CI)§	Estimated frequency (%)	OR (95% CI)‡	OR (95% CI)§
CAA	41.0	1.26 (1.08-1.46)†	1.27 (1.08-1.49)†	38.7	1.12 (0.98-1.28)	1.17 (1.02-1.36)*	37.3	1.02 (0.94-1.12)	1.03 (0.94-1.13)
CGA	35.3	1.03 (0.88-1.20)	1.05 (0.90-1.24)	-	-	-	-	-	-
GGA	11.9	0.77 (0.62-0.96)*	0.74 (0.58-0.94)*	12.6	0.89 (0.74-1.08)	0.89 (0.74-1.08)	12.3	0.98 (0.87-1.11)	1.00 (0.87-1.14)
CGT	11.2	0.75 (0.59-0.95)*	0.72 (0.55-0.92)*	11.8	1.02 (0.84-1.25)	1.01 (0.81-1.26)	13.0	1.06 (0.93-1.20)	1.05 (0.92-1.20)

IS, ischemic stroke; OR, odds ratio; CI, confidence interval. An additive model in binary logistic regression was used. ‡ Adjusted for age, and sex. § Adjusted for age, sex, hypertension, diabetes mellitus, and smoking. *P<0.05, †P<0.01