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. 2013 Sep 25;8(9):e76329. doi: 10.1371/journal.pone.0076329

Figure 8. Hsp-27-mediated neuroprotection following DPC transplantation in stroke.

Figure 8

Hsp27 appears to be targeted by DPCs for neuroprotection in stroke. Following intracerebral transplantation, DPCs survived in the stroke brain and elevate Hsp27 expression which may afford rescue of the ischemic penumbra proximal, as well as distal from the transplant site. Although the transplanted cells do not migrate far from the transplant site, the anti-oxidative stress protein Hsp27 is able to amplify the neuroprotection.