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. 2013 Sep 25;8(9):e74705. doi: 10.1371/journal.pone.0074705

Figure 5. Reduced adiposity is sufficient to improve insulin sensitivity.

Figure 5

(A) Fat mass, expressed as % of body weight, in HFD-fed mice supplemented or not with leucine and in HFD-pairfat mice (n = 10–11 per group). (B) Energy expenditure in HFD-fed water and pairfat mice (n = 6 per group). (C) Glucose tolerance and (D) insulin tolerance tests carried out in HFD-fed mice supplemented or not with leucine and in pairfat mice. Data are expressed as % of the HFD-water group (n = 10–11 per group). (E) G6Pase activity measured in the jejunum of HFD-fed water and pairfat mice (n = 6 per group). (F) Glucose-stimulated insulin secretion from Langerhans islets of HFD-fed water and pairfat mice (n = 3 mice per group, two independent experiments). Data are relative to 11 mM secretion in HFD-water mice that was considered 100%. * p<0.05 vs. HFD-water group; # p<0.05 vs. 3 mM condition in each group.