Table 1.

Baseline Characteristics by age, sex, and race

	Overall	Age		Sex		Race
		52–64 y	65–75 y	Female	Male	White	Black
No. of participants	11,060	6,674	4,386	6,178	4,882	8632	2428
Age (y)	62.8 ± 5.7	58.9 ± 2.6	68.8 ±3.2	62.5 ± 5.6	63.2 ± 5.7***	63.1 ± 5.6	61.8 ± 5.7***
Female sex	55.8%	58.1%	52.5%***	100%	0%	53.5%	64.3%***
Black race	22.0%	24.6%	17.9%***	25.3%	17.7%***	0%	100%
History of CVD	13.9%	11.2%	18.0%***	10.3%	18.5%***	13.6%	14.9%
Current smoker	14.9%	16.9%	11.8%***	14.0%	16.0%***	14.0%	17.7%***
Antihypertensive medication	43.4%	38.6%	50.6%***	43.6%	43.1%	39.0%	58.8%***
Systolic BP (mmHg)	127.6 ± 19.0	124.8 ± 18.1	131.8 ± 19.0***	128.1 ± 19.6	126.9 ± 18.2**	125.8 ± 18.4	133.6 ± 19.9***
Diastolic BP (mmHg)	71.0 ± 10.3	72.2 ± 10.1	69.2 ± 10.4***	70.1 ± 10.3	72.2 ± 10.2***	69.7 ± 9.9	75.8 ± 10.5***
Hypertension	47.4%	42.0%	55.5%***	49.0%	45.4%***	42.0%	66.6%***
Diabetes	16.6%	15.5%	18.5%***	15.6%	17.9%**	13.9%	26.4%***
Total Cholesterol (mmol/L)	5.2 ± 1.0	5.2 ± 1.0	5.2 ± 0.9	5.4 ± 1.0	5.0 ± 0.9***	5.2 ± 1.0	5.2 ± 1.0
Body Mass Index (kg/m2)	28.8 ± 5.6	29.1 ± 5.8	28.3 ± 5.4***	29.1 ± 6.3	28.4 ± 4.5***	28.3 ± 5.2	30.6 ± 6.4***
eGFR (mL/min/1.73m2)	84.1 ± 15.5	87.9 ± 14.8	78.3 ± 14.8***	84.5 ± 15.7	83.6 ± 15.2**	82.6 ± 13.9	89.6 ± 19.5***
ACR (mg/g)	3.7 [1.8–7.8]	3.4 [1.6–6.8]	4.4* [2.0–10.0]	4.3 [1.4–7.3]	3.1 *[2.1–8.3]	2.7 [0.8–8.9]	4.0***[2.0–7.7]

eGFR: estimated glomerular filtration rate; ACR: albumin-creatinine ratio. BP, blood pressure; CVD, cardiovascular disease;

Note: Values for categorical variables are given as percentages; values for continuous variables are given as mean ± standard deviation or median [interquartile range]. p-values were generated by ANOVA or Chi-square test, as appropriate.

^*p<0.05;

^**p<0.01;

^***p<0.001