Table 3.
Hazard ratios of cardiovascular disease for categories of eGFR and ACR by subgroups according to age, sex, and race
| Age Subgroups | ||||||||
|---|---|---|---|---|---|---|---|---|
| eGFR category | Age < 65 y | Age ≥ 65 y | ||||||
| ACR < 30 | ACR = 30–299 | ACR ≥ 300 | Overall | ACR < 30 | ACR = 30–299 | ACR ≥ 300 | Overall | |
| ≥90 | 1.00 (reference) | 1.49 (1.14–1.96) | 3.34 (2.20–5.08) | 1.00 (reference) | 1.00 (reference) | 1.45 (1.04–2.01) | 2.98 (1.65–5.36) | 1.00 (reference) |
| 60–89 | 1.17 (1.03–1.33) | 1.62 (1.19–2.21) | 4.60 (2.89–7.32) | 1.17 (1.04–1.31) | 1.09 (0.94–1.26) | 1.36 (1.06–1.74) | 1.56* (1.01–2.40) | 1.04 (0.91–1.19) |
| 45–59 | 1.43 (0.99–2.05) | 3.68 (2.16–6.27) | 3.80 (1.41–10.21) | 1.62 (1.21–2.17) | 1.57 (1.27–1.96)0 | 2.51 (1.82–3.45) | 2.82 (1.67–4.76) | 1.56 (1.29–1.87) |
| 30–44 | 0.78 (0.19–3.12) | 3.27 (1.54–6.92) | 4.39 (1.95–9.87) | 1.65 (0.98–2.77) | 2.04 (1.36–3.06) | 3.40 (1.89–6.09) | 7.00 (4.19–11.68) | 2.29 (1.71–3.08) |
| <30 | 4.04 (0.57–28.84) | -- | 5.77 (3.37–9.86) | 2.37 (1.38–4.07) | 1.96 (0.48–7.91) | 2.21 (0.70–6.93) | 4.12 (2.03–8.37) | 1.68 (0.95–2.97) |
| All | 1.00 (reference) | 1.50 (1.24–1.82) | 3.12 (2.37–4.09) | -- | 1.00 (reference) | 1.38 (1.18–1.62) | 2.00* (1.56–2.56) | -- |
| Sex Subgroups | ||||||||
| eGFR category | Female | Male | ||||||
| ACR < 30 | ACR = 30–299 | ACR ≥ 300 | Overall | ACR < 30 | ACR = 30–299 | ACR ≥ 300 | Overall | |
| ≥90 | 1.00 (reference) | 1.64 (1.20–2.23) | 3.87 (2.45–6.13) | 1.00 (reference) | 1.00 (reference) | 1.28 (0.96–1.71) | 2.36 (1.42–3.92) | 1.00 (reference) |
| 60–89 | 1.08 (0.93–1.25) | 1.79 (1.35–2.38) | 2.92 (1.85–4.62) | 1.06 (0.92–1.21) | 1.05 (0.93–1.19) | 1.13* (0.88–1.46) | 1.64 (1.06–2.54) | 1.02 (0.91–1.15) |
| 45–59 | 1.48 (1.12–1.94) | 3.26 (2.17–4.89) | 3.97 (1.96–8.07) | 1.59 (1.27–2.00) | 1.39 (1.11–1.76) | 2.01 (1.41–2.88) | 2.28 (1.25–4.17) | 1.38 (1.13–1.68) |
| 30–44 | 1.68 (0.96–2.94) | 4.66 (2.54–8.54) | 8.94 (4.41–18.14) | 2.34 (1.63–3.38) | 1.83 (1.09–3.08) | 2.01 (1.00–4.07) | 4.66 (2.72–8.00) | 1.79 (1.27–2.53) |
| <30 | 1.67 (0.41–6.72) | 5.23 (0.73–37.29) | 5.38 (2.65–10.89) | 2.11 (1.14–3.89) | 4.68 (0.65–33.49) | 1.37 (0.34–5.52) | 4.41 (2.58–7.55) | 1.74 (1.05–2.89) |
| All | 1.00 (reference) | 1.77 (1.48–2.13) | 3.15 (2.41–4.12) | -- | 1.00 (reference) | 1.18* (1.00–1.39) | 1.92* (1.50–2.46) | -- |
| Race Subgroups | ||||||||
| eGFR category | White | Black | ||||||
| ACR < 30 | ACR = 30–299 | ACR ≥ 300 | Overall | ACR < 30 | ACR = 30–299 | ACR ≥ 300 | Overall | |
| ≥90 | 1.00 (reference) | 1.46 (1.12–1.92) | 3.32 (2.06–5.35) | 1.00 (reference) | 1.00 (reference) | 1.43 (1.02–2.00) | 2.92 (1.79–4.77) | 1.00 (reference) |
| 60–89 | 1.01 (0.90–1.12) | 1.25 (0.99–1.57) | 1.72 (1.14–2.59) | 0.98 (0.88–1.08) | 1.26* (1.04–1.53) | 1.69 (1.20–2.38) | 3.01 (1.83–4.97) | 1.23* (1.04–1.47) |
| 45–59 | 1.39 (1.14–1.70) | 2.26 (1.64–3.12) | 3.06 (1.82–5.15) | 1.41 (1.19–1.68) | 1.51 (1.03–2.22) | 2.89 (1.78–4.71) | 2.12 (0.79–5.74) | 1.55 (1.15–2.10) |
| 30–44 | 1.52 (0.99–2.34) | 3.34 (1.83–6.09) | 6.41 (3.76–10.95) | 1.92 (1.42–2.60) | 3.22 (1.43–7.29) | 2.76 (1.36–5.62) | 4.98 (2.44–10.19) | 2.24 (1.43–3.49) |
| <30 | 1.99 (0.64–6.20) | 1.24 (0.17–8.87) | 5.76 (2.97–11.16) | 2.03 (1.16–3.56) | -- | 2.56 (0.63–10.39) | 4.50 (2.56–7.92) | 1.87 (1.09–3.22) |
| All | 1.00 (reference) | 1.39 (1.20–1.62) | 2.38 (1.89–3.01) | -- | 1.00 (reference) | 1.42 (1.15–1.76) | 2.33 (1.74–3.13) | -- |
Note: eGFRs are given in mL/min/1.73 m ; ACRs in mg/g. Associations given as hazard ratio (95% confidence interval).
Abbreviations: eGFR: estimated glomerular filtration rate; ACR: albumin-creatinine ratio.
*
significant interaction comparing HRs in the same category between subgroups based on coefficients for product terms of each potential effect modifier and categories of eGFR and ACR.
Bold indicates statistically significant as compared to reference category
-- indicates no event