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. Author manuscript; available in PMC: 2014 Dec 31.
Published in final edited form as: Mol Immunol. 2013 Aug 1;56(4):423–433. doi: 10.1016/j.molimm.2013.06.008

Figure 1. Wnt signaling inhibits CTL activation.

Figure 1

Sorted OT1 cells were labeled with CFSE, then stimulated with 3 SI (antigen+B7 plus IL-12) in the presence of GSK3 inhibitor TWS119 at different concentrations. (A) Cell proliferation (CFSE dilution) was evaluated at day 2 and 3. (B) Fold expansion of CTLs 3 days after in vitro stimulation was calculated according to original input. Each sample included cells pooled from 5 to 30 individual wells of 24-well plates. (C) Expression of activation related molecules in CTLs cells at day 3 after stimulation. These are representatives of at least five independent experiments with similar results.