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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Crit Care Med. 2013 Oct;41(10):2379–2387. doi: 10.1097/CCM.0b013e318292316c

Figure 3. Impact of covariates on the estimated pharmacokinetic parameters.

Figure 3

Circles(red) and squares(blue) are patients in the normothermic and hypothermic groups, respectively. A/B. Estimates of volume distribution (V1) and time-invariant maximum velocity of metabolism at baseline (Vmax0) for each patient is positively-correlated with weight. C/D. Estimated time-dependent velocity of metabolism (Vmaxi) on the log scale is reduced with lower temperatures for the normothermic and hypothermic patients versus temperature.