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. Author manuscript; available in PMC: 2015 Apr 1.

Published in final edited form as: Neuropathol Appl Neurobiol. 2014 Apr;40(3):296–310. doi: 10.1111/nan.12053

Fig 3 — a) A dendrite (D) contains two plasma-lemmal membrane invaginations (arrows) the longer of which has a spiral arrangement. The dendrite lacks other sub-cellular organelles such as microtubules.

b) A tangentially sectioned dendrite (D) shows PrP^SSLOW accumulation associated with coated tubular structures (arrowheads) and small membrane invaginations. PrP^SSLOW is also present on membranes of adjacent processes.

c) A cross section of a dendrite (D) shows, at one pole, a marked increase in PrP^SSLOW labelled coated pits and sub-plasma-lemmal fused tubular membrane complexes.

d) A large uncoated dendritic (D) membrane invagination (arrow) showing PrP^SSLOW accumulation.

a: Uranyl acetate / lead citrate staining; b–d: immunogold labelling for PrP^SSLOW

Mag bars: a = 1 μm, b = 0.5 μm, c = 1 μm, d = 0.5 μm.