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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Virology. 2013 Jul 10;445(0):57–79. doi: 10.1016/j.virol.2013.06.006

Figure 3. DNA Recognition helices of E2 Proteins from Different Genera.

Figure 3

A. Recognition Helix Sequence Logos

Sequence logos were created for the recognition helix of all genera of PVs with more than six members. The structure of the recognition helix shown at the top is derived from PDB: 2AYB HPV6 E2 bound to DNA (Hooley et al., 2006). Logos were created using Weblogo (http://weblogo.berkeley.edu/logo.cgi) (Crooks et al., 2004).

B. Contacts between the Recognition Helix and DNA Binding Site

This figure was adapted from (Hegde, 2002; Hegde et al., 1998). It shows the contacts between residues in the recognition helix of BPV1 E2 (with residue numbers converted to match those shown in A) and the consensus DNA binding site. Solid arrows signify contacts with specific bases. Dotted arrows represent contacts with the phosphate backbone.