Table 2. E2 Associated proteins with Functional or Biochemical Validation.
E2 associated proteins validated by functional or biochemical analyses
| Domains | HPV Type | Gene Symbol | Synonyms | UniProt | Protein Name | Reference |
|---|---|---|---|---|---|---|
| E2 | HPV11 16 18 | AR | Uniprot: P10275 | Androgen receptor | (Wu et al., 2007a) | |
| C | HPV18 | BRCA1 | Uniprot: P38398 | Breast cancer type 1 susceptibility protein | (Kim et al., 2003) | |
| N | BPV1 | BRD4 | Uniprot: O60885 | Bromodomain-containing protein 4 | (Baxter et al., 2005) | |
| E2 | BPV1 AaPV1 CPV1 SfPV1 OcPV1 OvPV1 HPV 1 4 11 16 31 57 | BRD4 | Uniprot: O60885 | Bromodomain-containing protein 4 | (McPhillips et al., 2006) | |
| N | HPV16 | BRD4 | Uniprot: O60885 | Bromodomain-containing protein 4 | (Schweiger et al., 2006) | |
| N | SfPV1 HPV 11 31 | BRD4 | Uniprot: O60885 | Bromodomain-containing protein 4 | (Senechal et al., 2007) | |
| E2 | BPV1 HPV16 | BRD4 | Uniprot: O60885 | Bromodomain-containing protein 4 | (Smith et al., 2010) | |
| NC | HPV5 | BRD4 | Uniprot: O60885 | Bromodomain-containing protein 4 | (Wang et al., 2009a) | |
| N | HPV11 | BRD4 | Uniprot: O60885 | Bromodomain-containing protein 4 | (Wu et al., 2006) | |
| N | BPV1 HPV16 | BRD4 | Uniprot: O60885 | Bromodomain-containing protein 4 | (You et al., 2004) | |
| H | HPV5 | C1QBP | Uniprot: Q07021 | Complement component 1 Q subcomponent-binding protein, mitochondrial | (Lai et al., 1999) | |
| N | HPV18 | CASP8 | FLICE | Uniprot: Q14790 | Caspase-8 | (Thierry and Demeret, 2008) |
| N | HPV16 18 | CDC20 | Uniprot: Q12834 | Cell division cycle protein 20 homolog | (Bellanger et al., 2005) | |
| C | BPV1 HPV8 16 18 | CEBPA | Uniprot: P49715 | CCAAT/enhancer-binding protein alpha | (Hadaschik et al., 2003) | |
| C | BPV1 HPV8 16 18 | CEBPB | Uniprot: P17676 | CCAAT/enhancer-binding protein alpha (C/EBP alpha) | (Hadaschik et al., 2003) | |
| E2 | HPV16 | CFLAR | cFLIP | Uniprot: O15519 | CASP8 and FADD-like apoptosis regulator | (Wang et al., 2011) |
| E8^E2 | HPV31 | CHD6 | Uniprot: Q8TD26 | Chromodomain-helicase-DNA-binding protein 6 | (Fertey et al., 2010) | |
| E2 | HPV 9 | CLTA | Uniprot: P09496 | Clathrin light chain A | (Muller et al., 2012) | |
| E2 | HPV16 | CPSF4 | CPSF30 | Uniprot: O95639 | Cleavage and polyadenylation specificity factor subunit 4 | (Johansson et al., 2012) |
| N | HPV18 | CREBBP | CBP | Uniprot: Q92793 | CREB-binding protein | (Lee et al., 2000) |
| E2 | BPV1 | CUL3 | Uniprot: Q13618 | Cullin-3 | (Zheng et al., 2009) | |
| N | BPV1 HPV 11 16 | DDX11 | CHLR1 | Uniprot: Q96FC9 | Probable ATP-dependent RNA helicase DDX11 | (Parish et al., 2006a) |
| N H C | BPV1 HPV 8 18 | EP300 | p300 | Uniprot: Q09472 | Histone acetyltransferase p300 | (Muller et al., 2002) |
| E2 | BPV1 | EP300 | p300 | Uniprot: Q09472 | Histone acetyltransferase p300 | (Peng et al., 2000) |
| E2 | BPV1 HPV16 | EP400 | P400 | Uniprot: Q96L91 | E1A-binding protein p400 | (Smith et al., 2010) |
| N | HPV16 8 | FZR1 | CDH1 | Uniprot: Q9UM11 | Fizzy-related protein homolog | (Bellanger et al., 2005) |
| N | BPV1 | GPS2 | AMF1 | Uniprot: Q13227 | G protein pathway suppressor 2 | (Breiding et al., 1997) |
| E2 | BPV1 | GPS2 | AMF-1 | Uniprot: Q13227 | G protein pathway suppressor 2 | (Peng et al., 2000) |
| E2 | HPV11 16 18 | GRIP1 | Uniprot: Q9Y3R0 | Glutamate receptor-interacting protein 1 | (Wu et al., 2007b) | |
| E2 | HPV 16 | GTF2B | Uniprot: Q00403 | Transcription initiation factor IIB | (Muller et al., 2012) | |
| E8^E2 | HPV31 | HDAC1 | Uniprot: Q13547 | Histone deacetylase 1 | (Ammermann et al., 2008) | |
| E8^E2 | HPV31 | HDAC2 | Uniprot: Q92769 | Histone deacetylase 2 | (Ammermann et al., 2008) | |
| E8^E2 | HPV31 | HDAC3 | Uniprot: O15379 | Histone deacetylase 3 | (Ammermann et al., 2008) | |
| E8^E2 | HPV31 | HDAC3 | Uniprot: O15379 | Histone deacetylase 3 | (Powell et al., 2010) | |
| NH C | HPV18 | KAT2B | PCAF | Uniprot: Q92831 | Histone acetyltransferase KAT2B | (Lee et al., 2002a) |
| E2 | BPV1 HPV16 | KDM5C | JARID1C, SMCX, | Uniprot: P41229 | Lysine-specific demethylase 5C | (Smith et al., 2010) |
| E2 | HPV1 3 5 6 8 9 16 18 | KIF20A | Uniprot: O95235 | Kinesin-like protein KIF20A | (Muller et al., 2012) | |
| N | BPV1 HPV16 11 | KIF20A | Uniprot: O95235 | Kinesin-like protein KIF20A | (Yu et al., 2007) | |
| E2 | BPV1 HPV11 16 | KPNA3 | Uniprot: O00505 | Importin subunit alpha-3 | (Bian and Wilson, 2010) | |
| E2 | BPV1 HPV11 16 | KPNA5 | Uniprot: O15131 | Importin subunit alpha-6 | (Bian and Wilson, 2010) | |
| C | HPV16 | MDM2 | Uniprot: Q00987 | E3 ubiquitin-protein ligase Mdm2 | (Gammoh et al., 2009) | |
| N | BPV1 HPV8 18 | NAP1L1 | NAP1 | Uniprot: P55209 | Nucleosome assembly protein 1-like 1 | (Rehtanz et al., 2004) |
| E8^E2 | HPV31 | NcoR | Uniprot: O75376 | Nuclear receptor corepressor 1 | (Powell et al., 2010) | |
| N | HPV16 | NRIP | Uniprot: P48552 | Nuclear receptor-interacting protein 1 | (Chang et al., 2012) | |
| C | HPV18 | PARP1 | Uniprot: P09874 | Poly [ADP-ribose] polymerase 1 | (Lee et al., 2002b) | |
| E2 | HPV11 16 18 | PLAL1 | ZacI | Uniprot: Q9UM63 | Zinc finger protein PLAGL1 | (Wu et al., 2007b) |
| N | HPV5 | PLK1 | Uniprot: P53350 | Serine/threonine-protein kinase PLK1 | (Wang et al., 2009a) | |
| E2 | BPV1 | RPA1 | RPA-70 | Uniprot: P27694 | Replication protein A 70 kDa DNA-binding subunit | (Li and Botchan, 1993) |
| E8^E2 | HPV31 | SETDB1 | Uniprot: Q15047 | Histone-lysine N-methyltransferase SETDB1 | (Ammermann et al., 2008) | |
| H | HPV5 | SFRS1 | ASF, SF2, SFRS1 | Uniprot: Q07955 | Serine/arginine-rich splicing factor 1 | (Lai et al., 1999) |
| H | HPV5 | SFRS2 | SC35 | Uniprot: Q01130 | Serine/arginine-rich splicing factor 2 | (Lai et al., 1999) |
| H | HPV5 | SFRS7 | Uniprot: Q16629 | Serine/arginine-rich splicing factor 7 | (Lai et al., 1999) | |
| N | HPV18 | SKP2 | Uniprot: Q13309 | S-phase kinase-associated protein 2 | (Bellanger et al., 2010) | |
| N | BPV1 | SMARCA 2 | BRM | Uniprot: P51531 | Probable global transcription activator SNF2L2 | (Kumar et al., 2007) |
| E2 | HPV 18 | SMARCA 4 | Brg1 | Uniprot: P51532 | Transcription activator BRG1 | (Cha and Seo, 2011) |
| N C | HPV6 11 16 18 | SMARCB 1 | hSNF5 | Uniprot: Q12824 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 | (Cha and Seo, 2011) |
| N | HPV11 | SMC5 | Uniprot: Q8IY18 | Structural maintenance of chromosomes protein 5 | (Wu et al., 2006) | |
| N | HPV11 | SMC6 | Uniprot: Q96SB8 | Structural maintenance of chromosomes protein 6 | (Wu et al., 2006) | |
| N | BPV1 HPV11 16 18 | SMN1 | Uniprot: Q16637 | Survival motor neuron protein | (Strasswimmer et al., 1999) | |
| H | HPV5 | SNRNP70 | Uniprot: P08621 | U1 small nuclear ribonucleoprotein 70 kDa | (Lai et al., 1999) | |
| N C | BPV1 HPV18 | SP1 | Uniprot: P08047 | Transcription factor Sp1 | (Steger et al., 2002) | |
| H C | HPV18 8 | SP1 | Uniprot: P08047 | Transcription factor Sp1 | (Steger et al., 2002) | |
| C | HPV16 | SRSF1 | ASF SF2 | Uniprot: Q07955 | Serine/arginine-rich splicing factor 1 | (Bodaghi et al., 2009) |
| C | HPV16 | SRSF4 | Uniprot: Q08170 | Serine/arginine-rich splicing factor 4 | (Bodaghi et al., 2009) | |
| C | HPV16 | SRSF5 | Uniprot: Q13243 | Serine/arginine-rich splicing factor 5 | (Bodaghi et al., 2009) | |
| N C | BPV1 HPV18 | TAF1 | TAFII250 | Uniprot: P21675 | Transcription initiation factor TFIID subunit 1 | (Carrillo et al., 2004) |
| N C | HPV16 | TAF1 | TAFII250 | Uniprot: P21675 | Transcription initiation factor TFIID subunit 1 | (Centeno et al., 2008) |
| N C | BPV1 HPV18 | TAF6 | TAFII80 | Uniprot: P49848 | Transcription initiation factor TFIID subunit 6 | (Carrillo et al., 2004) |
| H C | HPV 8 | TAF7 | TAFII55 | Uniprot: Q15545 | Transcription initiation factor TFIID subunit 7 | (Enzenauer et al., 1998) |
| N | BPV1 HPV16 18 | TAX1BP1 | Uniprot: Q86VP1 | Tax1-binding protein 1 | (Wang et al., 2009b) | |
| N C | BPV1 HPV18 | TBP | Uniprot: P20226 | TATA-box-binding protein | (Carrillo et al., 2004) | |
| C | HPV 8 | TBP | Uniprot: P20226 | TATA-box-binding protein | (Enzenauer et al., 1998) | |
| E2 | HPV11 | TBP | Uniprot: P20226 | TATA-box-binding protein | (Hartley and Alexander, 2002) | |
| C | BPV1 | TBP | Uniprot: P20226 | TATA-box-binding protein | (Rank and Lambert, 1995) | |
| N | HPV16 | TFIIB | Uniprot: Q00403 | Transcription initiation factor IIB | (Benson et al., 1997) | |
| C | BPV1 | TFIIB | Uniprot: Q00403 | Transcription initiation factor IIB | (Rank and Lambert, 1995) | |
| N | BPV1 | TFIIB | Uniprot: Q00403 | Transcription initiation factor IIB | (Yao et al., 1998) | |
| H | HPV5 | TNPO3 | Uniprot: Q9Y5L0 | Transportin-3 | (Lai et al., 1999) | |
| E2 | HPV11 | TOP1 | TopoI | Uniprot: P11387 | DNA topoisomerase 1 | (Clower et al., 2006) |
| N | HPV16 | TOPBP1 | Uniprot: Q92547 | DNA topoisomerase 2-binding protein 1 | (Boner et al., 2002) | |
| C | HPV16 | TP53 | p53 | Uniprot: P04637 | Cellular tumor antigen p53 | (Massimi et al., 1999) |
| C | HPV 6 11 16 | TP53 | p53 | Uniprot: P04637 | Cellular tumor antigen p53 | (Parish et al., 2006b) |
| H | HPV5 | TRA2B | Uniprot: P62995 | Transformer-2 protein homolog beta | (Lai et al., 1999) | |
| E8^E2 | HPV31 | TRIM28 | Uniprot: Q13263 | Transcription intermediary factor 1-beta | (Ammermann et al., 2008) | |
| E2 | BPV1 HPV16 | UBE2I | UBC9 | Uniprot: P63279 | SUMO-conjugating enzyme UBC9 | (Wu et al., 2008) |
| E2 | HPV 1 3 5 8 9 11 18 | VPS39 | Uniprot: Q96JC1 | Vam6/Vps39-like protein | (Muller et al., 2012) |