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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Dev Biol. 2013 Aug 6;382(1):268–279. doi: 10.1016/j.ydbio.2013.07.027

Figure 6.

Figure 6

Clearance of sip1 and ets4 from oral ectoderm in response to nodal or not perturbation. A) Spatial effects of nodal and not MASOs. In nodal MASO treated embryos ets4 and sip1 transcription was detected in both oral and aboral ectoderm up to 24h. In not-MASO treated embryos, ets4 continues to be transcribed in the oral ectoderm, but oral clearance of sip1proceeded as in controls. All embryos were shown with the oral ectoderm facing left. B) Quantitative analysis of ets4 transcript levels. Increased Nodal signaling through knockdown of lefty led to a moderate reduction of ets4 abundance. This reduction was abolished by co-injection of not MASO.