Table 4.
Association between each cognitive domain score and each risk factor, using five multiple linear regression models that adjust for demographic variables*
| Attention | Executive | Language | Memory | Visuo spatial | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coef Test (95% CI) | Test statistic | P value | Coef (95% CI) | Test statistic | P value | Coef (95% CI) | Test statistic | P value | Coef (95% CI) | Test statistic | P value | Coef (95% CI) | Test statistic | P value | |
| Chronic Mild Worry | 0.02 (−0.07,0.11) | 0.25 | 0.61 | −0.01 (−0.10, 0.07) | 0.07 | 0.79 | 0.01 (−0.08, 0.10) | 0.09 | 0.81 | 0.01 (−0.08, 0.10) | 0.09 | 0.76 | −0.02 (−0.14, 0.10) | 0.08 | 0.77 |
| Chronic Severe Anxiety | −0.14 (−0.22, −0.06) | 11.83 | <0.001 | −0.20 (−0.28, −0.13) | 27.64 | <0.001 | −0.16 (−0.24, −0.08) | 13.02 | <0.001 | −0.15 (−0.22, −0.07) | 13.02 | <0.001 | −0.20 (−0.31, −0.10) | 13.96 | <0.001 |
| Recent Onset Anxiety | −0.16 (−0.30, −0.02) | 5.06 | 0.02 | −0.19 (−0.32, −0.06) | 7.83 | 0.005 | −0.08 (−0.21, 0.06) | 0.46 | 0.26 | −0.05 (−0.18, 0.09) | 0.46 | 0.49 | −0.30 (−0.48, −0.11) | 9.90 | 0.002 |
| Total mCES-D score >5 | −0.02 (−0.04, −0.01) | 8.15 | 0.004 | −0.03 (−0.05, −0.02) | 18.30 | <0.001 | −0.03 (−0.05, −0.02) | 21.63 | <0.001 | −0.04 (−0.05, −0.02) | 21.63 | <0.001 | −0.04 (−0.06, −0.02) | 13.96 | <0.001 |
| Core mood Depression profile |
−0.06 (−0.12, −0.01) | 4.59 | 0.03 | −0.08 (−0.13, −0.03) | 9.17 | 0.002 | −0.07 (−0.12, −0.01) | 3.13 | 0.01 | −0.05 (−0.10, 0.01) | 3.13 | 0.07 | −0.09 (−0.17, −0.02) | 5.86 | 0.01 |
| Self-esteem/Interpersonal Depression profile |
−0.05 (−0.09, 0.00) | 4.07 | 0.04 | −0.06 (−0.11, −0.02) | 8.97 | 0.002 | −0.08 (−0.12, −0.03) | 21.68 | <0.001 | −0.10 (−0.15, −0.06) | 21.68 | <0.001 | −0.10 (−0.16, −0.04) | 10.35 | <0.001 |
| Apathy/Neurovegetative Depression profile |
−0.08 (−0.13, −0.04) | 12.02 | <0.001 | −0.12 (−0.16, −0.08) | 28.99 | <0.001 | −0.10 (−0.15, −0.05) | 30.55 | <0.001 | −0.13 (−0.17, −0.08) | 30.55 | <0.001 | −0.14 (−0.21, −0.08) | 18.80 | <0.001 |
CI = confidence interval; Coef= coefficient estimate; mCES-D= modified Center for Epidemiological Studies– Depression Scale; test statistic= Wald chi-squared test statistic with one degree of freedom.
Risk factors are Chronic Mild Worry, Chronic Severe Anxiety, Recent Onset Anxiety, dichotomized total mCES-D score (<5 or ≥5), Core mood depression profile, Self-esteem/Interpersonal Depression profile, Apathy/Neurovegetative Depression profile; demographic variables are age, gender, education level, and race; each change in cognitive domain score was obtained from the estimated slope of a mixed-effect model of cognitive domain value in which the predictor was time.