Table 6.
Concentrations of each taste compound that produced a significant change in preference scores relative to indifference (50%)
| Avidity (Significantly >50%) |
Avoidance (Significantly <50%) |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Taste Compound | NZW | BTBR | BTBR/NZW Congenic | BTBR/BTBR Control | Itpr3 WT | Itpr3 KO | NZW | BTBR | BTBR/NZW Congenic | BTBR/BTBR Control | Itpr3 WT | Itpr3 KO |
| Saccharin | 1+ | 10 | 1+ | − | 0.32+ | − | − | − | − | − | − | − |
| Sucrose | 4%+ | 8%+ | 1%+ | 16%+ | 1%+ | 8%+ | − | − | − | − | − | − |
| Maltose | 0.5%+ | 4%+ | 0.5%+ | 4%+ | 1%+ | 4%+ | − | − | − | − | − | − |
| Polycose | 1%+ | 2%+ | 0.5%+ | 16%+ | 0.5%+ | 4%+ | − | − | − | 0.5–2% | − | 1% |
| MSG | 10–178 | 32 | 10–320 | 10–100 | 10–178 | 100–178 | 562 | 178+ | 562 | 562 | 316+ | 316+ |
| IMP | 3.2–32 | − | 1–100 | 1–100 | 1–32 | − | 100 | 100 | 100+ | 100+ | 316 | 316 |
| Na3HP2O7 | 3.2–32 | 10 | 1–10 | 1,10 | 5.6–56 | − | 100 | 56+ | 56+ | 32+ | 100+ | 56+ |
| HCl | − | − | 0.32 | − | 0.1–3.2 | 0.32–3.2 | 3.2+ | 1+ | 3.2+ | 1+ | 10 | 10 |
| Citric acid | − | − | 0.32, 3.2 | 0.1–0.32 | 0.1–0.32 | 0.1–0.32 | 0.1, 3.2+ | 0.1+ | 10 | 10 | 10 | 10 |
| Denatonium | − | 0.01 | − | 0.01, 0.32–1 | − | 0.03–0.32 | 0.32+ | 3.16 | 0.32+ | − | 0.32+ | 3.2 |
| QHCl | − | − | − | − | − | 0.1 | 0.01+ | 0.1 | 0.032+ | − | 0.01+ | − |
| Caffeine | − | 1–3.2 | − | − | 3.16 | − | 10+ | 32 | 10 | 10 | 1, 10+ | 10+ |
| ZnCl2 | − | − | − | − | 3.2–10 | − | 3.2+ | 3.2+ | 10+ | 10+ | 100 | 32+ |
| Capsaicin | − | − | − | − | − | − | 0.001+ | 0.001+ | 0.001+ | 0.001+ | 0.001+ | 0.003+ |
| CaCl2 | − | 7.5–25 | − | 10–32 | − | 10–32 | 7.5+ | − | 32+ | 100 | 10+ | 100 |
| CaLa | − | 7.5–75 | − | 10–32 | − | 3.2+ | 7.5+ | − | 10+ | − | 3.2+ | − |
| MgCl2 | − | − | − | − | − | − | 10+ | 100 | 100 | 100 | 10+ | 100 |
| NaCl | − | − | 32–178 | 32–178 | − | − | 316+ | 178 | 316+ | 316+ | 316+ | 178+ |
| NaLa | 32–178 | 32–178 | 32–100 | − | 32–178 | 100–178 | 562 | 320+ | 320+ | 178+ | 562 | 562 |
| KCl | − | − | 32–178 | − | 32–178 | − | 10, 100+ | 316 | 316+ | 178+ | 316+ | 316+ |
| NH4Cl | − | − | 3.2–100 | 32 | − | 32 | 316 | 316 | 316 | 316 | 316 | 316 |
Values are determined from two-bottle choice experiments, according to one-sample t-tests. Values are concentrations in millimoles or percent (%). −, No concentration was preferred (left columns) or avoided (right columns); +, all higher concentrations tested also influenced preferences.