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. 2013 Sep 26;7:30. doi: 10.3389/fnana.2013.00030

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Copyright © Mitew, Kirkcaldie, Dickson and Vickers.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Double-immunofluorescence labeling of representative thioflavin-S plaques and NF⁺ neurites from preclinical AD (A,B), end-stage AD (D,E), APP/PS1 (G,H), and Tg2576 (J,K) transgenic mice shows classical bulb-like swellings containing neurofilaments indicated by filled arrowheads in the plaque-core, small arrows at the plaque edge, and large arrows in the periphery. Normal-appearing neurites in association with thioflavin-S labeled fibrillar plaques are indicated by unfilled arrowheads. A large proportion of NF⁺ neurites associated with Aβ plaques are dystrophic (blue fraction: C,F,I,L) and there is extensive neruite loss in end-stage AD and Tg2576 mice (gray fraction: F,L).