Table 1.

Effect of treatment with melatonin on brain oxidative stress biomarkers in ovariectomized and Al-intoxicated ovariectomized rats

Groups	Parameters
	H2O2 (mmol/mg protein)	MDA (nmol/mg protein)
Gonad intact control	6.90 × 10−3±3.23 × 10−4	5.60 ± 0.30
Ovx control	9.30 × 10−3 ± 4.00 × 10−4 (34.78 %)	6.40 ± 0.34 (14.28 %)
Ovx + melatonin	7.31 × 10−3±3.39 × 10−4 (−21.37 %)	5.70 ± 0.29 (−10.93 %)
Al-intoxicated control	3.40 × 10−2±1.86 × 10−3b (265.59 %)	9.60 ± 0.40b (50 %)
Ovx + Al + melatonin	1.80 × 10−2 ± 1.90 × 10−3c (−47.05 %)	6.55 ± 0.34c (−31.77 %)

Data are represented as Mean ± SE (10 rats/group)

Ovx ovariectomized

^bsignificant change at p < 0.05 in comparison with ovariectomized control group

^csignificant change at p < 0.05 in comparison with Al-intoxicated control group

(%) percent of difference with respect to corresponding control value