FIG. 1.

(a) Ingenuity network generated by mapping the genes differentially expressed between tumor and control thyroid tissue. The network is graphically displayed with genes as nodes (different shapes represent the functional classes of the gene products) and the biological relationships between the nodes as lines. A solid line without arrow indicates protein–protein interaction. Arrows indicate the direction of action of one gene to another. (b, c) Plk-1 expression profiling by real-time PCR and protein levels using thyroid pools from 4-month-old control and single-mutant mice, ATC-free, progressively older (4, 6, and 8 months) double mutants, and histologically confirmed ATCs from 8- to 9-month-old double mutants. ATC, anaplastic thyroid carcinoma; PCR, polymerase chain reaction.