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HDAC3 modulates memory formation in a Nr4a2-dependent manner. (A) HDAC3-FLOX mice with dorsal hippocampal deletion of Hdac3 exhibit significantly enhanced long-term memory as compared to wild-type littermates (both groups received RISC free control). In contrast, siRNA-Nr4a2–treated HDAC3-FLOX mice exhibit no enhanced memory. (B) qRT-PCR shows that siRNA against Nr4a2 significantly reduces Nr4a2 expression in both HDAC3-FLOX and wild-type littermates.
