. Author manuscript; available in PMC: 2014 Sep 1.

Published in final edited form as: J Dev Behav Pediatr. 2013 Sep;34(7):508–522. doi: 10.1097/DBP.0b013e31829d1f20

Table 3.

Promising Measures of Maladaptive Behavior

Domain	Potential Outcome Measure	Pros	Cons

Irritability/aggression	ABC-Irritability	Known sensitivity in ID/AUT. FXS psychometric data	Sensitivity in FXS unknown. Limited to lower functioning patients

Anxiety	PARS	Good phenotype coverage; sensitive in pediatric anxiety trials, existing FXS psychometric data Validated for ID; limited FXS psychometric data	Limited data in ID and FXS sensitive unknown.
Anxiety	ADAMS		Unclear validity for higher functioning patients

Hyperactivity/impulsivity	Connors/SNAP-IV	Sensitive in ADHD trials	Validity in FXS unknown

Inattention	Connors/SNAP-IV	Sensitive in ADHD trials	Validity in FXS unknown

Social reciprocity/avoidance	SRS	Good coverage of domains; linked to broad autism phenotype	Validity in FXS unknown
Social reciprocity/avoidance	ADAMS (social avoidance) ABC – Lethargy/withdrawal	FXS reliability and validity data FXS reliability and validity data	Sensitivity unknown Lethargy confounded with social items (however, see 81)

Repetitive/compulsive behaviors	Repetitive Behavior Scale-Revised	Good coverage of domains; validated in autism/ID	Limited FXS data.

Adaptive behavior	Vineland	Extensive FXS data; sensitive in double blind FXS trials	A by parental expectations and environment; wide period of observation

Self-injury	Behavior Problems Inventory	Published FXS data; severity and frequency ratings	Sensitivity to treatment unknown