. Author manuscript; available in PMC: 2013 Sep 26.

Published in final edited form as: Curr Opin HIV AIDS. 2011 Nov;6(6):465–471. doi: 10.1097/COH.0b013e32834b55c7

Table 1. Performance of serum marker panels to assess liver fibrosis/cirrhosis in HIV/HCV co-infected patients, 2010-2011.

				≥F2 (significant fibrosis)		≥F3 (advanced fibrosis)		≥F4 (cirrhosis) AUROC
				≥F2 (significant fibrosis)		≥F3 (advanced fibrosis)		≥F4 (cirrhosis) AUROC

Score	Serum Markers	Reference	N	%	AUROC	%	AUROC	%	AUROC
Direct
	Hyaluronic acid (HA)	[9]	201	58	0.67	32	0.77	11	0.86
	Matrix metalloproteinase 2 (MMP-2)	[10]	90	66	0.64	37	---	18	0.79
	Tissue inhibitor of metalloproteinase-1 (TIMP-2)	[10]	90	66	0.57	37	---	18	0.64

Indirect
APRI	Platelets, AST	[9,11-17]^A	2025^B^,^C	43-81	0.67-0.79	15-34	0.76-0.82	8-20	0.80
FIB-4	Age, Platelets, AST, ALT	[9,11-15,17]^A	1506^B^,^C	43-81	0.67-0.76	15-34	0.69-0.85	8-20	0.82
Forns Index	Age, Platelets, GGT, Cholesterol	[9,13-16]	1178	43-58	0.67-0.74	15-32	0.75-0.78	8-12	0.82
HGM-1	Platelets, AST, Glucose	[9,14,15]	563	57-58	0.78-0.80	27-32	---	11	---
HGM-2	Platelets, AST, Alkaline Phosphatase, INR,	[9,13-15]	659	43-58	---	15-32	0.80-0.85	8-11	0.92
HICV	Alpha-2-macroglobulin, AST, Prothrombin Index	[17]^A	444	66-72	0.73-0.82	33-34	---	10-20	---
Artificial Neuronal Network (ANN)	Fibrinogen, glucose, AST, ALT, GGT, ALP, cholesterol, platelet count, INR, age	[14]	362	56	0.85	27	0.87	11	---
Direct & Indirect
HGM-3	Platelets, Alkaline Phosphatase, HA, TIMP-1, Hepatocyte growth factor (HGF)	[15]	195	58	0.78	31	0.93	12	0.93
Fibrometer	Age, Sex, Alpha-2-macroglobulin Platelets, AST, HA, Prothrombin Index, Urea	[17]^A	444	66-72	0.74-0.78	33-34	---	10-20	---
Fibrometer HICV	Age, Sex, Alpha-2-macroglobulin Platelets, AST, HA, Prothrombin Index, Urea	[17]^A	275	66-72	0.74-0.83	33-34	---	10-20	---
Fibrometer 2G	Age, Sex, Alpha-2-macroglobulin Platelets, AST, HA, Prothrombin Index, Urea	[18]	176	67	0.82	33	---	20	----
Fibrometer 3G	Age, Sex, Alpha-2-macroglobulin Platelets, AST, Prothrombin Index, Urea	[18]	176	67	0.83	33	---	20	----
Hepascore	Age, Sex, Alpha-2-macroglobulin, GGT, Bilirubin, Hyaluronic acid (HA)	[17]^A	444	66-72	0.69-0.78	33-34	---	10-20	---

Includes data from derivation and validation populations.

Liver fibrosis stage was assessed using the Batts-Ludwig system for 105 samples

Data included from 295 biopsies sampled from 237 patients. Liver fibrosis stage was assessed using the Ishak Histologic Activity Index (HAI) and Ishak 4–6 fibrosis represented advanced fibrosis corresponding to Metavir >F3.