Table 2.
Top FKBP5 eQTL (P < 0.05) association results for response, remission, and percentage change in QIDS-C after SSRI treatment (on the basis of logistic regression adjustment for four eigen vectors)
| rs SNP | Chr. | Annotated gene | Position | Response (last visit)
|
Response (8 weeks)
|
% change in QIDS-C
|
|||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | Spearman | P-value | ||||
| FKBP5 eQTLs associated with the response outcome and percent change in QIDS-C after SSRI treatment (P < 0.05) | |||||||||
| rs11045870 | 12 | SLCO1B1 | 21371075 | 0.71 (0.51–0.98) | 0.034 | NS | NS | NA | NS |
| rs11045871 | 12 | SLCO1B1 | 21372224 | 0.71 (0.51–0.98) | 0.034 | NS | NS | NA | NS |
| rs235317 | 21 | PTTG1P | 46275047 | 0.76(0.58–0.99) | 0.041 | 0.64 (0.47–0.87) | 0.005 | NA | NS |
| rs7960384 | 12 | – | 21395908 | 0.72 (0.52–1.00) | 0.049 | NS | NS | NA | NS |
| rs4964463 | 12 | POLR3B | 106789188 | 1.58 (1.07–2.32) | 0.021 | 1.64 (1.02–2.62) | 0.040 | 0.080 | 0.006 |
| rs4603275 | 11 | CNTN5 | 98320413 | 0.73 (0.54–0.99) | 0.041 | NS | NS | NA | NS |
| rs6595125 | 5 | DTWD2 | 117748700 | 1.31 (1.02–1.68) | 0.038 | 1.38 (1.02–1.86) | 0.038 | NA | NS |
| rs7173166 | 15 | BNC1 | 83934748 | NS | NS | 0.68 (0.50–0.94) | 0.021 | NA | NS |
| rs8027193 | 15 | HDGFRP3 | 83879618 | NS | NS | 0.67 (0.51–0.97) | 0.027 | NA | NS |
| rs4341707 | 15 | BNC1 | 83927857 | NS | NS | 0.71 (0.52–0.98) | 0.039 | NA | NS |
| rs17818663 | 9 | – | 13833407 | NS | NS | 0.65 (0.43–0.98) | 0.043 | NA | NS |
| rs352428 | 8 | FZD3 | 28478892 | NS | NS | 0.49 (0.32–0.76) | 0.002 | NA | NS |
| rs10965529 | 9 | DMRTA1 | 22943509 | 0.75 (0.58–0.98) | 0.031 | 0.66 (0.48–0.90) | 0.008 | NA | NS |
| rs11078539 | 17 | PLD2 | 4715977 | NS | NS | NS | NS | − 0.103 | 0.020 |
| rs2784113 | 1 | PTPRC | 198773703 | NS | NS | 0.71 (0.50–0.99) | 0.046 | NA | NS |
| rs SNP | Chr. | Annotated gene | Position | Remission (last visit)
|
Remission (8 weeks)
|
||||
| OR (95% CI) | P-value | OR (95% CI) | P-value | ||||||
|
| |||||||||
| FKBP5 eQTLs associated with the remission outcome after SSRI treatment (P < 0.05) | |||||||||
| rs235317 | 21 | PTTG1P | 46275047 | 0.74 (0.56–0.97) | 0.029 | 0.68 (0.50–0.91) | 0.001 | ||
| rs17818663 | 9 | – | 13833407 | NS | NS | 0.64 (0.43–0.96) | 0.030 | ||
| rs6502015 | 17 | TBCD | 80888164 | NS | NS | 1.41 (1.03–1.94) | 0.033 | ||
| rs4964463 | 12 | POLR3B | 106789188 | 1.69 (1.16–2.45) | 0.006 | 1.67 (1.1–2.53) | 0.016 | ||
| rs11650232 | 17 | DLG4 | 7088923 | 1.29 (1.00–1.67) | 0.047 | NS | NS | ||
| rs1479957 | 3 | MAGI1 | 65228662 | NS | NS | 1.65 (1.06–2.57) | 0.026 | ||
Highlighted in bold are the SNPs selected for replication study.
CI, confidence interval; eQTLs, expression quantitative trait locus; OR, odds ratio; QIDS-C, Quick Inventory of Depressive Symptomatology-Clinician Rated; SNP, single nucleotide polymorphism; SSRI, selective serotonin reuptake inhibitor.