Table 3.

Replication study

rs SNP	Last visit					6 weeks
	MAF					MAF
	Nonresponders	Responders	n	OR (95% CI)	P-value	Nonresponders	Responders	n	OR (95% CI)	P-value
SNPs associated with the response outcome after SSRI treatment in STAR*D
rs16878591	0.04	0.04	930	0.87 (0.58–1.31)	0.50	0.05	0.04	815	0.87 (0.57–1.32)	0.51
rs235317	0.32	0.32	933	0.98 (0.8–1.19)	0.80	0.32	0.32	816	1.00 (0.81–1.24)	0.97
rs34866878	0.03	0.02	917	0.76 (0.44–1.33)	0.33	0.03	0.02	802	0.78 (0.43–1.42)	0.42
rs352428	0.13	0.10	928	0.77 (0.58–1.02)	0.07	0.14	0.10	812	0.74 (0.54–1.00)	0.05
rs4964463	0.13	0.14	926	1.08 (0.82–1.41)	0.59	0.14	0.14	813	1.02 (0.76–1.35)	0.91
rs9380524	0.11	0.09	923	0.83 (0.62–1.11)	0.21	0.11	0.09	808	0.85 (0.62–1.18)	0.33
rs SNP	Last visit					6 weeks
	MAF					MAF
	Remitters	Nonremitters	n	OR (95% CI)	P-value	Remitters	Nonremitters	n	OR (95% CI)	P-value
SNPs associated with the remission outcome after SSRI treatment in STAR*D
rs16878591	0.04	0.04	933	0.97 (0.64–1.47)	0.89	0.04	0.04	815	0.98 (0.64–1.49)	0.91
rs235317	0.31	0.33	936	1.10 (0.90–1.35)	0.35	0.31	0.33	816	1.11 (0.89–1.37)	0.36
rs34866878	0.03	0.02	920	0.57 (0.31–1.06)	0.06	0.03	0.02	802	0.61 (0.32–1.16)	0.12
rs352428	0.13	0.10	931	0.79 (0.59–1.07)	0.13	0.13	0.10	812	0.74 (0.54–1.02)	0.06
rs4964463	0.14	0.14	929	0.98 (0.75–1.28)	0.87	0.15	0.13	813	0.91 (0.68–1.21)	0.52
rs9380524	0.11	0.10	926	0.89 (0.66–1.21)	0.45	0.10	0.10	808	0.93 (0.67–1.28)	0.65

Highlighted in bold is the SNP that shows the lowest P-value for both last visit and 6 weeks response.

Selected SNPs were genotyped in STAR*D white non-Hispanic patient samples (excluding low baseline Ham-D patients) and associated with SSRI treatment outcomes, including response and remission.

CI, confidence interval; MAF, minor allele frequency; OR, odds ratio; SNP, single nucleotide polymorphism; SSRI, selective serotonin reuptake inhibitor; STAR*D, Sequenced Treatment Alternatives to Relieve Depression.