Table 2.
Intensity and extent of staining of apoptotic markers from non-labouring and post-labour SC and distal fetal membranes.
| Antigen | Tissue | Intensity of staining | Extent of staining | |||||
|---|---|---|---|---|---|---|---|---|
| No-labour | Post-labour | No-labour | Post-labour | |||||
| DS | SCS | SOR | DS | SCS | SOR | |||
| Intrinsic pathway | Bax | Amnion | 1.8 ± 0.2 | 1.7 ± 0.2 | 1.2 ± 0.2 | 3.2 ± 0.0 | 3.8 ± 0.2 | 1.8 ± 0.2* |
| Chorion | 2.0 ± 0.0 | 2.0 ± 0.0 | 2.0 ± 0.4 | 3.2 ± 0.4* | 4.2 ± 0.3 | 2.5 ± 0.2* | ||
| Smac | Amnion | 0.0 ± 0.0* | 0.8 ± 0.2 | 0.8 ± 0.8 | 0.0 ± 0.0 | 0.7 ± 0.3 | 0.8 ± 0.9 | |
| Chorion | 1.0 ± 0.0* | 1.7 ± 0.2 | 1.5 ± 0.2 | 1.8 ± 0.4* | 3.5 ± 0.2 | 2.3 ± 0.6 | ||
|
| ||||||||
| Extrinsic pathway | Fas | Amnion | 1.8 ± 0.2 | 1.8 ± 0.2 | 1.8 ± 0.2 | 4.3 ± 0.2 | 3.8 ± 0.3 | 4.0 ± 0.3 |
| Chorion | 3.3 ± 0.3 | 2.0 ± 0.5 | 2.0 ± 0.2 | 3.5 ± 0.3* | 4.3 ± 0.2 | 4.0 ± 0.4 | ||
| FasL | Amnion | 2.0 ± 0.0 | 2.0 ± 0.3 | 2.0 ± 0.0 | 1.7 ± 0.2 | 1.8 ± 0.5 | 2.5 ± 0.4 | |
| Chorion | 2.0 ± 0.0 | 2.5 ± 0.2 | 2.0 ± 0.2 | 3.0 ± 0.0* | 4.0 ± 0.3 | 3.0 ± 0.3* | ||
|
| ||||||||
| Common terminal pathway | Caspase-3 | Amnion | 0.0 ± 0.0* | 0.7 ± 0.2 | 0.5 ± 0.2 | 0.0 ± 0.0 | 0.5 ± 0.2 | 0.7 ± 0.3 |
| Chorion | 1.0 ± 0.0* | 1.7 ± 0.2 | 1.0 ± 0.0* | 1.8 ± 0.3* | 3.5 ± 0.2 | 2.7 ± 0.5 | ||
| PARP | Amnion | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | |
| Chorion | 2.0 ± 0.0 | 1.8 ± 0.3 | 1.2 ± 0.2 | 3.0 ± 0.3* | 4.0 ± 0.3 | 0.8 ± 0.3* | ||
|
| ||||||||
| Antiapoptotic | Bcl-2 | Amnion | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| Chorion | 0.0 ± 0.0 | 0.17 ± 0.2 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | ||
All data is expressed as mean ± SEM (n = 6 patients per group).
*P < 0.05 versus SCS (no-labour SCS versus no-labour DS analysed by paired sample comparison; no-labour SCS versus post-labour SOR analysed by Student's t-test).