Table 2.
Mean estimates (SD) of mitotic activity (SMI, MAI) in different TNM stages and clinical stages of 130 Libyan female patients with breast cancer. The significance of correlation of stage features and proliferative features is shown as P values evaluated with ANOVA and t-test.
| Group | No. of patients | SMI (SD) | P value | MAI (SD) | P value |
|---|---|---|---|---|---|
| *T Stage | 0.03 | 0.06 | |||
| T1 | 6 | 14.0 (11.3) | 9.0 (9.2) | ||
| T2 | 45 | 28.5 (18.8) | 26.6 (18.7) | ||
| T3 | 44 | 37.0 (25.4) | 27.4 (19.2) | ||
| T4 | 35 | 33.5 (16.3) | 31.0 (17.3) | ||
| **N stage | 0.007 | 0.02 | |||
| N0 | 27 | 21.5 (13.0) | 20.6 (19.7) | ||
| N1 | 69 | 34.2 (23.6) | 28.6 (18.4) | ||
| N2 | 32 | 34.7 (16.7) | 28.1 (16.1) | ||
| N3 | 2 | 60.1 (25.7) | 57.5 (6.4) | ||
| ***M stage | 0.06 | 0.1 | |||
| M0 | 113 | 30.8 (20.0) | 26.3 (18.4) | ||
| M1 | 16 | 41.3 (25.7) | 33.9 (18.7) | ||
| Clinical stage | 0.002 | 0.07 | |||
| 1 | 6 | 15.7 (9.3) | 10.8 (8.1) | ||
| 2 | 44 | 25.0 (14.5) | 26.3 (20.8) | ||
| 3 | 64 | 36.1 (22.2) | 27.8 (16.7) | ||
| 4 | 16 | 41.3 (21.0) | 33.9 (18.7) |
*T stage: extent of the primary neoplasm; **N stage: lymph node status: extent of lymph node involvement; ***M stage: distant metastasis, present/absent.