Table 2.

Frequencies of memory T cells and regulatory T cells

	Control	HSCT	Natalizumab	P-value
CD4	55·8 (50·4–66·4)	44·1 (33·3–53·5)	64·5 (49·3–69·2)	0·003
CD45RO	30·3 (21·2–45·0)	49·1 (35·6–65·0)	37·1 (29·3–46·7)	0·06
FoxP3+	2·93 (2·47–3·75)	3·00 (2·76–3·39)	1·87 (1·60–2·64)	0·006
Helios+	7·74 (6·07–9·27)	8·84 (7·33–10·7)	5·98 (4·30–7·82)	0·04
pTreg	1·20 (0·90–1·45)	1·33 (1·16–1·91)	1·18 (0·76–1·58)	NS
nTreg	1·89 (1·15–2·59)	1·54 (1·22–1·85)	0·84 (0·45–1·13)	0·001
pTreg/nTreg	0·55 (0·42–1·06)	0·74 (0·62–1·57)	1·19 (0·81–2·99)	0·03

HSCT, haematopoietic stem cell transplant; nTreg, natural regulatory T cells; pTreg, peripheral regulatory T cells.

Medians (interquartile range). CD4⁺ is a percentage of CD3⁺ cells. All other numbers are percentages of total CD3⁺ CD4⁺ cells. pTreg is defined as CD3⁺ CD4⁺ Helios^– FoxP3⁺. nTreg is defined as CD3⁺ CD4⁺ Helios⁺ FoxP3⁺. P-values are given for the Kruskal–Wallis test.