Table 2.
Cytokine and chemokine levels (pg/ml) in lung cell culture supernatants of wild-type or interleukin-17 receptor subunit A-deficient (IL-17RA−/−) mice before and 5 or 12 weeks after Mycobacterium tuberculosis infection
| Lungs | Uninfected | 5 weeks post-infection | 12 weeks post-infection | |||
|---|---|---|---|---|---|---|
| Wild-type | IL-17RA−/− | Wild-type | IL-17RA−/− | Wild-type | IL-17RA−/− | |
| IL-6 | 211 | < 2·2 | 5109 | 2301 | 6227 | 1508 |
| IL-1β | < 34·3 | < 34·3 | 223 | 364 | 298 | 1030 |
| KC | 1175 | 272 | 1133 | 602 | 2701 | 1284 |
| IP-10 | < 9·8 | 19 | 878 | 796 | 1595 | 2634 |
| IL-10 | 104 | < 5·4 | 434 | < 5·4 | 631 | 100 |
| TNF-α | 10 | 12 | 212 | 105 | 396 | 403 |
IL-6, interleukin-6; IP-10, CXCL10; KC, CXCL1; TNF-α, tumour necrosis factor-α.