Table 2.
Gene frequencies of HLA-A* and B* alleles and KIR-HLA receptor–ligand pairs in highly exposed and persistently seronegative (HESN), HIV-1+ couples, HIV-1+ patients and controls
| HLA alleles and KIR combination | (1) HESN n = 23 n (%) | (2) Couples + n = 23 n (%) | (3) HIV+ n = 100 n (%) | (4) Controls n = 200 n (%) | Statistical finding | ||
|---|---|---|---|---|---|---|---|
| 1 versus 2 Pc | 1 versus 3 Pc | 1 versus 4 Pc | |||||
| A*23 | 2 (9) | 2 (9) | 4 (4) | 15 (7) | ns | ns | ns |
| A*24 | 2 (9) | 5 (22) | 24 (24) | 40 (20) | ns | ns | ns |
| A*25 | 2 (9) | 0 | 5 (5) | 11 (5·5) | ns | ns | ns |
| A*32 | 7 (30) | 0 | 1 (1) | 11 (5·5) | 0·009 | 0·00002* | 0·0007 |
| B*27 | 0 | 1 (4·3) | 6 (6) | 10 (6) | ns | ns | ns |
| B*38 | 1 (4·3) | 3 (13) | 4 (4) | 3 (1·5) | ns | ns | ns |
| B*44 | 10 (43) | 3 (13) | 8 (8) | 34 (17) | 0·049 | 0·0001* | 0·005* |
| B*51 | 3 (13) | 3 (13) | 10 (10) | 26 (13) | ns | ns | ns |
| B*52 | 3 (13) | 0 | 3 (3) | 9 (4·5) | 9 (4·5) | 9 (4·5) | 9 (4·5) |
| B*57 | 1.(4·3) | 0 | 6 (6) | 6 (3) | ns | ns | ns |
| A-Bw4-80I | 13 (56) | 6 (26) | 34 (34) | 70 (35) | ns | ns | ns |
| B-Bw4-80I | 7 (30) | 8 (35) | 38 (38) | 77 (38) | ns | ns | ns |
| Bw4+- 80T | 10 (43) | 3 (13) | 24 (24) | 68 34) | 0·049 | ns | ns |
| 3DS1/3DL1-A*32 | 7 (30) | 0 | 0 | 4 (2) | 0·009* | 0·00003* | 0·00001* |
| 3DS1/3DL1-B*44 | 8 (35) | 0 | 1 (1) | 20 (10) | 0·003* | 0·000003* | 0·003* |
| 3DL1/3DL1-B*44 | 2 (9) | 3 (13) | 7 (7) | 8 (4) | ns | ns | ns |
| Yates corrected and * two-tailed Fisher exact test were used for P-values. | |||
| Exact confidence limit | |||
| A*32 | HESN versus HIV-1+ couples: OR (95 % CI) = Undefined, Relative Risk = 2·44 (1·67 < RR < 3·55) | 3DS1/3DL1-A*32 | HESN versus HIV-1+ couples: OR (95% CI) = Undefined, RR 2·44 (1·67 < RR < 3·55) |
| HESN versus patients HIV-1+: OR (95% CI) = 43·31 (4·75 < OR < 1001·95) | HESN versus HIV-1+ patients: OR (95% CI) = Undefined, RR = 7·25 (4·60 < RR < 11·43 | ||
| B*44 | HESN versus Controls: OR (95% CI) = 43·31 (4·81 < OR < 1970,28) | 3DS1/3DL1-B*44 | HESN versus Controls : OR(95% CI) = 21·44 (4·91 < OR < 99·79 |
| HESN versus HIV1+ couples: OR (95% CI) = 5·13 (1·02 < OR < 33·30) | HESN versus HIV-1+ couples: OR (95% CI) = Undefined, RR = 2·53 (1·71 < RR < 11·43) | ||
| HESN versus patients HIV-1+: OR (95% CI) = 8·85 (2·56 < OR < 30·49) | HESN versus HIV-1+ patients: OR (95% CI) = 52·80 (6·04 < OR < 2364·63) | ||
| HESN versus controls : OR (95% CI) = 3·76 (1·34 < OR < 10·09) | HESN versus Controls: OR (95% CI) = 4·80 (1·62 < OR < 14·3) | ||